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Multi-Drug Resistance

Known as: Multidrug Resistance, Resistance, Multiple Drug, Multiple drug resistance 
Simultaneous resistance to a spectrum of unrelated drugs following exposure to a single agent. Mechanisms involve expression of multidrug efflux… 
National Institutes of Health

Related topics

Related topics

50 relations
ABCA1 protein, humanABCB1 2 AlleleABCB1 geneABCB1 protein, human

Broader (1)

Drug resistance

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense.
Review
1999
Review
1999
The multidrug resistance protein family.
Review
1996
Review
1996
Proton-dependent multidrug efflux systems
Multidrug efflux systems display the ability to transport a variety of structurally unrelated drugs from a cell and consequently… 
Highly Cited
1994
Highly Cited
1994
Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.
Amplification of the gene encoding multidrug resistance-associated protein (MRP) and overexpression of its cognate mRNA have been… 
Highly Cited
1994
Highly Cited
1994
Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.
The multidrug resistance-associated protein (MRP) is a 180- to 195-kDa glycoprotein associated with multidrug resistance of human… 
Review
1992
Review
1992
Is the multidrug transporter a flippase?
Highly Cited
1990
Highly Cited
1990
Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.
The resistance of tumor cells to chemotherapeutic drugs is a major obstacle to successful cancer chemotherapy. In human cells… 
Highly Cited
1989
Highly Cited
1989
Expression of Multidrug Resistance Gene in Human Cancers
Highly Cited
1986
Highly Cited
1986
Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance
Increased expression of P-glycoprotein, a plasma membrane glycoprotein of relative molecular mass (Mr) 170,000 (170K), occurs in… 
Highly Cited
1978
Highly Cited
1978
Quantitation of differential sensitivity of human-tumor stem cells to anticancer drugs.
With a direct in vitro tumor-colony assay developed to measure sensitity of human-tumor stem cells to anticancer drugs, we… 
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