• Publications
  • Influence
Astrocytic Purinergic Signaling Coordinates Synaptic Networks
The results indicate that astrocytes are intricately linked in the regulation of synaptic strength and plasticity and provide a pathway for synaptic cross-talk. Expand
Glutamate-mediated astrocyte–neuron signalling
Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated. Expand
Astrocyte control of synaptic transmission and neurovascular coupling.
The application of subcellular imaging of Ca2+ signaling to astrocytes now provides functional data to support this structural notion that both excitatory and inhibitory signals provided by the same glial cell act in concert to regulate neuronal function. Expand
Tripartite synapses: glia, the unacknowledged partner
It is suggested that perisynaptic Schwann cells and synaptically associated astrocytes should be viewed as integral modulatory elements of tripartite synapses. Expand
Neuronal Synchrony Mediated by Astrocytic Glutamate through Activation of Extrasynaptic NMDA Receptors
The results reveal a distinct mechanism for neuronal excitation and synchrony and highlight a functional link between astrocytic glutamate and extrasynaptic NMDA receptors. Expand
Glia: listening and talking to the synapse
  • P. Haydon
  • Biology, Medicine
  • Nature Reviews Neuroscience
  • 1 March 2001
It is no longer appropriate to consider solely neuron–neuron connections; it is also necessary to develop a view of the intricate web of active connections among glial cells, and between glia and neurons. Expand
Gliotransmitters Travel in Time and Space
It is proposed that astrocytes mainly signal through high-affinity slowly desensitizing receptors to modulate neurons and perform integration in spatiotemporal domains complementary to those of neurons. Expand
The tripartite synapse: roles for gliotransmission in health and disease.
In addition to being essential supporters of neuronal function, astrocytes are now recognized as active elements in the brain. Astrocytes sense and integrate synaptic activity and, depending onExpand
Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss
It is concluded that astrocytes modulate the accumulation of sleep pressure and its cognitive consequences through a pathway involving A1 receptors. Expand
Synaptic Islands Defined by the Territory of a Single Astrocyte
A new structurally based conceptual framework is offered to evaluate functional data involving interactions between neurons and astrocytes in the mammalian brain by proposing the concept of functional islands of synapses in which groups of synapse confined within the boundaries of an individualAstrocyte are modulated by the gliotransmitter environment controlled by that astroCyte. Expand