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Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.
Gene expression levels and immunolocalization of organic ion transporters in the human kidney.
- H. Motohashi, Yuji Sakurai, K. Inui
- BiologyJournal of the American Society of Nephrology…
- 1 April 2002
Results suggest that hOOAT1, hOAT3, and hOCT2 play predominant roles in the transport of organic ions across the basolateral membrane of human proximal tubules.
Cisplatin and Oxaliplatin, but Not Carboplatin and Nedaplatin, Are Substrates for Human Organic Cation Transporters (SLC22A1–3 and Multidrug and Toxin Extrusion Family)
- A. Yonezawa, S. Masuda, Sachiko Yokoo, T. Katsura, K. Inui
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 November 2006
Results indicate that cisplatin is a relatively good substrate of hOCT1, hO CT2, and hMATE1, and oxaliplatin has the potential to play predominant roles in the tissue distribution and anticancer effects and/or adverse effects of platinum agent-based chemotherapy.
Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.
- S. Masuda, T. Terada, K. Inui
- Biology, ChemistryJournal of the American Society of Nephrology…
- 1 August 2006
Results indicate that hMATE2-K is a new human kidney-specific H+/organic cation antiporter that is responsible for the tubular secretion of cationic drugs across the brush border membranes.
Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.
- T. Mikkaichi, Takehiro Suzuki, T. Abe
- BiologyProceedings of the National Academy of Sciences…
- 9 March 2004
Human OATP4C1/rat Oatp4c1 might be a first step of the transport pathway of digoxin and various compounds into urine in the kidney, which is one of the most commonly prescribed drugs for the treatment of heart failure.
Cellular and molecular aspects of drug transport in the kidney.
Detailed information concerning molecular and cellular aspects of drug transporters expressed in the kidney has facilitated studies of the mechanisms underlying renal disposition as well as transporter-mediated drug interactions.
Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.
It is suggested that metformin is a superior substrate for renal OCT2 rather than hepatic OCT1, and renal OCT 2 plays a dominant role for metformIn pharmacokinetics.
Involvement of Human Multidrug and Toxin Extrusion 1 in the Drug Interaction between Cimetidine and Metformin in Renal Epithelial Cells
Results suggest that apical hMATE1 is involved in drug interactions between cimetidine and cationic compounds in the proximal tubular epithelial cells.
Cloning and Functional Characterization of a Novel Rat Organic Anion Transporter Mediating Basolateral Uptake of Methotrexate in the Kidney*
The findings suggest that the rat OAT-K1 is localized in the basolateral membranes of renal tubules, where it mediates renal clearance of methotrexate from the blood.