P-Glycoprotein

Known as: p-gp, PGY-1 Protein, P-Glycoprotein [Chemical/Ingredient] 
A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1956-2017
010020019562016

Papers overview

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Highly Cited
2009
Highly Cited
2009
P-glycoprotein (P-gp) detoxifies cells by exporting hundreds of chemically unrelated toxins but has been implicated in multidrug… (More)
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Highly Cited
2001
Highly Cited
2001
P-glycoprotein (Pgp) affects the absorption, distribution, and clearance of a variety of compounds. Thus, identification of… (More)
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Highly Cited
2001
Highly Cited
2001
A large body of evidence suggests that an increase in the brain beta-amyloid (Abeta) burden contributes to the etiology of… (More)
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Highly Cited
2000
Highly Cited
2000
P-glycoprotein, a member of the ATP-binding cassette transporter family, is able to confer resistance on tumors against a large… (More)
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Highly Cited
1998
Highly Cited
1998
P-glycoprotein actively transports a wide variety of chemically diverse compounds out of the cell. Based on a comparison of a… (More)
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Highly Cited
1996
Highly Cited
1996
Xenobiotics frequently induce proteins involved in their detoxification. Because many drugs that are metabolized by human… (More)
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Highly Cited
1991
Highly Cited
1991
Hematopoietic stem cells show reduced staining with a mitochondrial fluorescent dye, rhodamine 123 (Rh-123), which was supposed… (More)
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Highly Cited
1990
Highly Cited
1990
P-glycoprotein is a highly conserved membrane protein shown to be overexpressed in many multidrug-resistant tumor cell lines. P… (More)
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Highly Cited
1985
Highly Cited
1985
One reason for the failure of chemotherapy in the treatment of advanced cancers may be the outgrowth of multidrug-resistant… (More)
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Highly Cited
1976
Highly Cited
1976
Chinese hamster ovary cells selected for resistance to colchicine display pleiotropic cross-resistance to a wide range of… (More)
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