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P-Glycoprotein

Known as: p-gp, PGY-1 Protein, P-Glycoprotein [Chemical/Ingredient] 
A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a… Expand
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
The recently determined C. elegans P-glycoprotein (Pgp) structure revealed significant deviations compared to the original mouse… Expand
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Highly Cited
2009
Highly Cited
2009
P-glycoprotein (P-gp) detoxifies cells by exporting hundreds of chemically unrelated toxins but has been implicated in multidrug… Expand
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Highly Cited
2005
Highly Cited
2005
Thirty-two structurally diverse drugs used for the treatment of various conditions of the central nervous system (CNS), along… Expand
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Review
2003
Review
2003
P-glycoprotein, the most extensively studied ATP-binding cassette (ABC) transporter, functions as a biological barrier by… Expand
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Highly Cited
2001
Highly Cited
2001
P-glycoprotein (Pgp) affects the absorption, distribution, and clearance of a variety of compounds. Thus, identification of… Expand
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Highly Cited
2000
Highly Cited
2000
P-glycoprotein, a member of the ATP-binding cassette transporter family, is able to confer resistance on tumors against a large… Expand
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Highly Cited
1994
Highly Cited
1994
We have generated mice homozygous for a disruption of the mdr1a (also called mdr3) gene, encoding a drug-transporting P… Expand
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Highly Cited
1991
Highly Cited
1991
Hematopoietic stem cells show reduced staining with a mitochondrial fluorescent dye, rhodamine 123 (Rh-123), which was supposed… Expand
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Highly Cited
1985
Highly Cited
1985
One reason for the failure of chemotherapy in the treatment of advanced cancers may be the outgrowth of multidrug-resistant… Expand
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Highly Cited
1976
Highly Cited
1976
Chinese hamster ovary cells selected for resistance to colchicine display pleiotropic cross-resistance to a wide range of… Expand
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