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Association Between Common Genetic Variants in Pre‐microRNAs and Gastric Cancer Risk in Japanese Population
Background: Common single‐nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be associated with susceptibility to several human cancers. We evaluated the associations of three… Expand
Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis.
Interleukin-17A (IL-17A) and IL-17F play a role in tissue inflammation by inducing release of proinflammatory and neutrophil-mobilizing cytokines. We investigated the associations between gastric… Expand
Toll‐like receptor 2 –196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer
Toll like receptors (TLR) play important roles in the signaling of many pathogen‐related molecules and endogenous proteins associated with immune activation. The –196 to –174del polymorphism affects… Expand
Preoperative staging of superficial esophageal carcinoma: comparison of an ultrasound probe and standard endoscopic ultrasonography.
- N. Hasegawa, Y. Niwa, T. Arisawa, S. Hase, H. Goto, T. Hayakawa
- Gastrointestinal endoscopy
- 1 October 1996
BACKGROUND In diagnosing superficial esophageal carcinoma, it is necessary to differentiate mucosal carcinoma from submucosal carcinoma because mucosal carcinoma has a good prognosis and local… Expand
The Influence of Polymorphisms of Interleukin-17A and Interleukin-17F Genes on the Susceptibility to Ulcerative Colitis
We investigated the association between ulcerative colitis (UC) and polymorphisms of IL-17A (rs2275913, G-197A) and IL-17F (rs763780, 7488T/C) genes. We employed the multiplex PCR-SSCP method to… Expand
Prevalence of gallbladder polyps among apparently healthy Japanese: ultrasonographic study.
- K. Segawa, T. Arisawa, +6 authors N. Ohmiya
- The American journal of gastroenterology
- 1 May 1992
The prevalence of gallbladder polyps was investigated in apparently healthy Japanese who underwent abdominal ultrasonography as part of their health screening examination. The polyps found were… Expand
Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3'-UTR, influence susceptibility to gastric cancer.
We report an association between gastric cancer (GC) and polymorphisms in IL17A, rs2275913 (-197 G > A), rs3748067 (*1249 C > T), and pri-miR-938, rs2505901 (T > C). We employed the multiplex… Expand
Effect of MDR1 gene promoter methylation in patients with ulcerative colitis.
- T. Tahara, T. Shibata, +14 authors T. Arisawa
- Biology, Medicine
- International journal of molecular medicine
- 1 April 2009
Altered MDR1 expression and/or function contribute to the pathogenesis of inflammatory bowel disease (IBD). DNA methylation was shown as an important mechanism in gene silencing. We investigated DNA… Expand
Evidence-based clinical practice guidelines for functional dyspepsia
General interest in functional gastrointestinal disorders is increasing among Japanese doctors as well as patients. This increase can be attributed to a number of factors, including recent increased… Expand
Association Study of Common Genetic Variants in Pre-microRNAs in Patients with Ulcerative Colitis
- Masaaki Okubo, T. Tahara, +12 authors T. Arisawa
- Journal of Clinical Immunology
- 1 February 2011
BackgroundCommon single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be associated with susceptibility to several human diseases. We evaluated the associations of three… Expand