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Drug Efflux

Transport of drugs out of a cell. A mechanism of drug resistance.
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
Platinum complexes are clinically used as adjuvant therapy of cancers aiming to induce tumor cell death. Depending on cell type… Expand
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Highly Cited
2010
Highly Cited
2010
Multidrug transporter proteins are best known for their contributions to chemoresistance through the efflux of anticancer drugs… Expand
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Highly Cited
2010
Highly Cited
2010
The treatment options of leishmaniasis are limited and far from satisfactory. For more than 60 years, treatment of leishmaniasis… Expand
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Highly Cited
2010
Highly Cited
2010
Overexpression of drug efflux transporters such as P-glycoprotein (Pgp) protein is one of the major mechanisms for multiple drug… Expand
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Review
2009
Review
2009
Chemoresistance presents a general health problem concerning the therapy of infectious disease and cancer. In this context, the… Expand
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Review
2007
Review
2007
P-glycoprotein actively transports structurally unrelated compounds out of cells, conferring the multidrug resistance phenotype… Expand
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Review
2005
Review
2005
Resistance to drug treatment is an important hurdle in the therapy of many brain disorders, including brain cancer, epilepsy… Expand
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Highly Cited
2004
Highly Cited
2004
A subset of stem cells, termed the "side population" (SP), has been identified in several tissues in mammalian species. These… Expand
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Highly Cited
2002
Highly Cited
2002
ABSTRACT Campylobacter jejuni, a gram-negative organism causing gastroenteritis in humans, is increasingly resistant to… Expand
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Highly Cited
2001
Highly Cited
2001
This investigation describes the expression and interindividual variability in transcript levels of multiple drug efflux systems… Expand
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