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Drug Efflux

Transport of drugs out of a cell. A mechanism of drug resistance.
National Institutes of Health

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41 relations
ABCA1 protein, humanABCB1 2 AlleleABCB1 geneABCB1 protein, human

Papers overview

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Highly Cited
2008
Highly Cited
2008
Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain
Highly Cited
2008
Highly Cited
2008
Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1.
Highly Cited
2004
Highly Cited
2004
P-glycoprotein expression and distribution in the rat placenta during pregnancy.
Highly Cited
2002
Highly Cited
2002
The multidrug resistance of tumour cells was reversed by tetrandrine in vitro and in xenografts derived from human breast adenocarcinoma MCF-7/adr cells.
Highly Cited
2000
Highly Cited
2000
Methotrexate cross-resistance in a mitoxantrone-selected multidrug-resistant MCF7 breast cancer cell line is attributable to enhanced energy-dependent drug efflux.
Cellular resistance to the antifolate methotrexate (MTX) is often caused by target amplification, uptake defects, or alterations… 
Highly Cited
1998
Highly Cited
1998
Characterization of the Regional Intestinal Kinetics of Drug Efflux in Rat and Human Intestine and in Caco-2 Cells
AbstractPurpose. The aim of the present study was to investigate the transport kinetics of intestinal secretory processes in the… 
Highly Cited
1998
Highly Cited
1998
Bryostatin 1 down-regulates mdr1 and potentiates vincristine cytotoxicity in diffuse large cell lymphoma xenografts.
The down-regulation of multidrug resistance (mdr1) gene expression as detected by competitive reverse transcription-PCR and the… 
Highly Cited
1998
Highly Cited
1998
Existence of a p-glycoprotein drug efflux pump in cultured rabbit conjunctival epithelial cells.
PURPOSE To determine whether a p-glycoprotein (P-gp) drug efflux pump exists in cultured rabbit conjunctival epithelial cells… 
Highly Cited
1996
Highly Cited
1996
Correlation between rhodamine 123 accumulation and azole sensitivity in Candida species: possible role for drug efflux in drug resistance
A wide variety of prokaryotic and eukaryotic cells exhibit a multidrug resistance (MDR) phenotype, indicating that resistance to… 
Highly Cited
1983
Highly Cited
1983
Membrane transport, sulfhydryl levels and DNA cross-linking in Chinese hamster ovary cell mutants sensitive and resistant to melphalan.
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