Drug Efflux

Transport of drugs out of a cell. A mechanism of drug resistance.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1980-2018
05010015019802018

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Highly Cited
2011
Highly Cited
2011
Platinum complexes are clinically used as adjuvant therapy of cancers aiming to induce tumor cell death. Depending on cell type… (More)
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Highly Cited
2010
Highly Cited
2010
Multidrug transporter proteins are best known for their contributions to chemoresistance through the efflux of anticancer drugs… (More)
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Highly Cited
2006
Highly Cited
2006
Drug efflux systems play a major role in resistance to a wide range of noxious compounds in several Gram negative species. Here… (More)
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Highly Cited
2004
Highly Cited
2004
A subset of stem cells, termed the "side population" (SP), has been identified in several tissues in mammalian species. These… (More)
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Highly Cited
2004
Highly Cited
2004
Multidrug resistance among Gram-negative bacteria is conferred by three-component membrane pumps that expel diverse antibiotics… (More)
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Highly Cited
2004
Highly Cited
2004
Imatinib (Glivec®, STI571) is an intracellular acting drug that demonstrates high activity against BCR-ABL-positive chronic… (More)
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Highly Cited
2002
Highly Cited
2002
Campylobacter jejuni, a gram-negative organism causing gastroenteritis in humans, is increasingly resistant to antibiotics… (More)
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Highly Cited
2001
Highly Cited
2001
The hematopoietic stem cell underlying acute myeloid leukemia (AML) is controversial. Flow cytometry and the DNA-binding dye… (More)
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Highly Cited
2001
Highly Cited
2001
This investigation describes the expression and interindividual variability in transcript levels of multiple drug efflux systems… (More)
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Highly Cited
1998
Highly Cited
1998
Multidrug resistance mediated by the drug efflux protein, P-glycoprotein (P-gp), is one mechanism that tumor cells use to escape… (More)
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