• Publications
  • Influence
Effects of dietary chemopreventive phytochemicals on P-glycoprotein function.
The effects of dietary phytochemicals on P-glycoprotein function were investigated using human multidrug-resistant carcinoma KB-C2 cells and the fluorescent P-glycoprotein substrates daunorubicin andExpand
  • 149
  • 9
Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals
PurposeFor the development of a safe and effective dual inhibitor of anticancer drug efflux transporters P-glycoprotein and multidrug resistance protein 1 (MRP1) to conquer multidrug resistance, weExpand
  • 103
  • 8
Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1.
The effects of dietary chemopreventive citrus phytochemicals on the drug efflux transporters P-glycoprotein (ABCB1) and multidrug resistance protein 1 (MRP1, ABCC1) were investigated usingExpand
  • 46
  • 6
Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells.
We studied the effects of flavonoids, naringenin (flavanone), baicalein (flavone), kaempferol, quercetin, myricetin, morin, and fisetin (flavonols) as well as two glycosides of quercetin onExpand
  • 97
  • 5
Inhibition of P‐glycoprotein function by tea catechins in KB‐C2 cells
We studied the effects of tea catechins, (‐)‐epicatechin (EC), (‐)‐epigallocatechin (EGC), (‐)‐epicatechin gallate (ECG), and (‐)‐epigallocatechin gallate (EGCG) on the P‐glycoprotein (P‐gp) functionExpand
  • 93
  • 5
Inhibitory effects of polyphenols on p-glycoprotein-mediated transport.
  • S. Kitagawa
  • Biology, Medicine
  • Biological & pharmaceutical bulletin
  • 2006
Overexpression of P-glycoprotein (P-gp), a plasma membrane transporter which extrudes chemotherapeutic agents out of cells, has been associated with the multidrug resistance (MDR) of cancer cells. ItExpand
  • 68
  • 5
  • PDF
Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals.
The effects of dietary antioxidative and chemopreventive rosemary phytochemicals on the function of the human drug efflux transporter P-glycoprotein (MDR1, ABCB1) and multidrug resistance protein 1Expand
  • 72
  • 4
Scavenging effects of dihydric and polyhydric phenols on superoxide anion radicals, studied by electron spin resonance spectrometry
We investigated the scavenging effects of dihydric, trihydric phenols and related polyphenols on superoxide anion radicals (O-2) generated form the hypoxanthine-xanthine oxidase system by ESRExpand
  • 48
  • 4
Studies on the constituents of Broussonetia species. II. Six new pyrrolidine alkaloids, broussonetine A, B, E, F and broussonetinine A and B, as inhibitors of glycosidases from Broussonetia kazinoki
Six new pyrrolidine alkaloids called broussonetine A, B, E, F, and broussonetinine A and B were isolated from the branches of Broussonetia kazinoki Sieb. (Moraceae). Broussonetine A, B, E and F wereExpand
  • 57
  • 4
Efficient topical delivery of chlorogenic acid by an oil-in-water microemulsion to protect skin against UV-induced damage.
We examined the intradermal delivery of a hydrophilic polyphenol chlorogenic acid by in vitro study using excised guinea pig dorsal skin and Yucatan micropig skin. Skin accumulation as well as theExpand
  • 37
  • 4
  • PDF