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Induction of NQO1 in cancer cells.
Publisher Summary This chapter focuses on induction of NAD[P]H:[quinone acceptor]oxidoreductase (NQO1) in cancer cells. NQO1 is a flavoenzyme that catalyzes obligatory two-electron reduction of… Expand
Clinical applications of quinone-containing alkylating agents.
- A. Begleiter
- Biology, Medicine
- Frontiers in bioscience : a journal and virtual…
- 1 November 2000
Quinone-containing alkylating agents are a class of chemical agents that have received considerable interest as anticancer drugs. These agents contain a quinone moiety that can be reduced and an… Expand
Role of NADPH cytochrome P450 reductase in activation of RH1
- A. Begleiter, M. Leith, D. Patel, B. Hasinoff
- Medicine, Biology
- Cancer Chemotherapy and Pharmacology
- 26 January 2007
PurposeRH1 is a new bioreductive agent that is an excellent substrate for the two-electron reducing enzyme, NAD(P)H quinone oxidoreductase 1 (NQO1). RH1 may be an effective NQO1-directed antitumor… Expand
Chlorambucil in chronic lymphocytic leukemia: mechanism of action.
Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries but the clinical presentation and rate of disease progression are highly variable. When treatment is required the… Expand
Expression of p53 predicts treatment failure in aggressive non-Hodgkin's lymphomas.
Approximately 50% of patients with aggressive non-Hodgkin's lymphomas (NHL) achieve a complete remission (CR) and cure with combination chemotherapy. The International Index is a useful clinical… Expand
Studies related to antitumor antibiotics. Part V. Reactions of mitomycin C with DNA examined by ethidium fluorescence assay.
- J. Lown, A. Begleiter, D. Johnson, A. Morgan
- Chemistry, Medicine
- Canadian journal of biochemistry
- 1 February 1976
The cytotoxic action of the antitumor antibiotic mitomycin C occurs primarily at the level of DNA. Using highly sensitive fluorescence assays which depend on the enhancement of ethidium fluorescence… Expand
Studies Related to Antitumor Antibiotics. Part VI. Correlation of Covalent Cross-linking of DNA by Bifunctional Aziridinoquinones with their Antineoplastic Activity
Certain bisaziridinopyrrolidinoquinone analogs, which contain the structural moieties essential for physiological activity in the parent antitumor agent mitomycin C, have been synthesized. These… Expand
Induction of DT-diaphorase in cancer chemoprevention and chemotherapy.
DT-diaphorase (EC 18.104.22.168) is a flavoprotein that catalyses two-electron reduction of quinones, quinone imines, and nitrogen oxides. It is a Phase II detoxifying enzyme that can detoxify chemically… Expand
Quinone-induced DNA damage and its relationship to antitumor activity in L5178Y lymphoblasts.
The presence of a quinone group in the structure of a series of model compounds was shown to produce cell kill by a mechanism involving free radicals and active oxygen species. Furthermore, the… Expand
Evidence for carrier-mediated transport of melphalan by L5178Y lymphoblasts in vitro.
Mechanism of transport of the alkylating agent [14C]melphalan was investigated in L5178Y lymphoblasts in vitro. A time course of melphalan uptake was approximately linear for 5 to 10 min and… Expand