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Blood-brain barrier P-glycoprotein function in Alzheimer's disease.
TLDR
Assessment of blood-brain barrier P-glycoprotein function in patients with Alzheimer's disease compared with age-matched healthy controls shows altered kinetics of (R)-[(11)C]verapamil in Alzheimer’s disease, similar to alterations seen in studies where P- glycoprotein is blocked by a pharmacological agent.
AAPS-FDA Workshop White Paper: Microdialysis Principles, Application and Regulatory Perspectives
TLDR
Although μD as a preclinical and clinical tool has been available for two decades, there is still uncertainty about the use of μD in drug research and development, both from a methodological and a regulatory point of view.
Impaired Target Site Penetration of Vancomycin in Diabetic Patients following Cardiac Surgery
TLDR
It is demonstrated that vancomycin penetration into target tissues is substantially impaired in diabetic patients versus nondiabetics and could possibly contribute to failure of antibiotic treatment and the development of antimicrobial resistance in diabetic Patients.
bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice
TLDR
It is demonstrated that bcl-2 antisense oligonucleotide treatment improves the chemo-sensitivity of human melanoma grown in severe combined im-munodeficient (SCID) mice and suggests that reduction of B cl-2 in melanoma may be a novel and rational approach to improve chemosensitivity and treatment outcome.
A clinical trial of a whole-virus H5N1 vaccine derived from cell culture.
TLDR
A two-dose vaccine regimen of either 7.5 microg or 15 microg of hemagglutinin antigen without adjuvant induced neutralizing antibodies against diverse H5N1 virus strains in a high percentage of subjects, suggesting that this may be a useful H5n1 vaccine.
Tariquidar-Induced P-Glycoprotein Inhibition at the Rat Blood–Brain Barrier Studied with (R)-11C-Verapamil and PET
TLDR
The data demonstrate that (R)-11C-verapamil PET combined with tariquidar administration is a promising approach to measure P-gp function at the blood–brain barrier of rats.
Penetration of Linezolid into Soft Tissues of Healthy Volunteers after Single and Multiple Doses
TLDR
It is suggested that linezolid concentrations in soft tissues can be considered sufficient to inhibit the growth of many clinically relevant bacteria.
Limitations of Small Animal PET Imaging with [18F]FDDNP and FDG for Quantitative Studies in a Transgenic Mouse Model of Alzheimer’s Disease
TLDR
The authors could not detect regionally increased [18F]FDDNP binding and regionally decreased FDG binding in the brains of Tg2576 transgenic versus wild-type mice.
Influence of MUC18/MCAM/CD146 expression on human melanoma growth and metastasis in SCID mice
TLDR
It is indicated that MCAM expression of human melanoma cells has an influence on later stages of the metastatic process only, namely, extravasation and establishment of new foci of growth, but is per se not sufficient for this process.
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