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6-chrysenamine

Known as: 6-chrysylamine, 6-chrysenylamine, chrysenex 
National Institutes of Health

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Related topics

3 relations

Broader (2)

Antineoplastic AgentsChrysenes

Narrower (1)

CP 1001

Papers overview

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1993
1993
Roles of human hepatic and pulmonary cytochrome P450 enzymes in the metabolism of the environmental carcinogen 6-nitrochrysene.
6-Nitrochrysene is remarkably tumorigenic in the lung and liver of newborn mice and approximates the activities of certain… 
1989
1989
Mutagenicity, metabolism and DNA adduct formation of 6-nitrochrysene in Salmonella typhimurium.
The mutagenic activities of 6-nitrochrysene (6-NC) and its previously identified metabolites were evaluated in Salmonella… 
1989
1989
Comparative tumorigenicity of 6-nitrochrysene and its metabolites in newborn mice.
The tumorigenic activities of 6-nitrochrysene and its metabolites were evaluated in the newborn mouse model. Groups of mice were… 
1988
1988
Metabolism of the carcinogen [3H]6-nitrochrysene in the preweanling mouse: identification of 6-aminochrysene-1,2-dihydrodiol as the probable proximate carcinogenic metabolite.
6-Nitrochrysene (NC) is a potent lung and liver carcinogen when administered in multiple doses to preweanling mice. We have… 
1988
1988
Metabolism of 6-nitrochrysene by intestinal microflora
Since bacterial nitroreduction may play a critical role in the activation of nitropolycyclic aromatic hydrocarbons, we have used… 
1987
1987
Identification of C8-modified deoxyinosine and N2- and C8-modified deoxyguanosine as major products of the in vitro reaction of N-hydroxy-6-aminochrysene with DNA and the formation of these adducts…
Since 6-nitrochrysene and 6-aminochrysene have shown activity in carcinogenicity bioassays, we have begun an investigation of… 
1987
1987
Carcinogen-DNA adduct formation in the lungs and livers of preweanling CD-1 male mice following administration of [3H]-6-nitrochrysene, [3H]-6-aminochrysene, and [3H]-1,6-dinitropyrene.
6-Nitrochrysene (NC) and 6-aminochrysene (AC) have been shown to be potent lung and liver carcinogens when administered in… 
1984
1984
Identification of trans-1,2-dihydro-1,2-dihydroxy-6-nitrochrysene as a major mutagenic metabolite of 6-nitrochrysene.
Liver 9000 X g supernatant from rats was used to study the metabolism of [6- 14C]nitrochrysene under aerobic conditions. The… 
Highly Cited
1975
Highly Cited
1975
Mutagenesis of certain activated carcinogens in vitro associated with genetically mediated increases in monooxygenase activity and cytochrome P 1-450.
1969
1969
Induction of Liver and Lung Tumours in Mice by 6-Aminochrysene administered during the First 3 Days of Life
IN 1953, Rudali and his colleagues1 reported the effects of 6-aminochrysene (Fig. 1) in mice and showed that this substance… 
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