The less harmful cigarette: a controversial issue. a tribute to Ernst L. Wynder.
- D. Hoffmann, I. Hoffmann, K. El-Bayoumy
- MedicineChemical Research in Toxicology
- 28 June 2001
The anticipated reduction of mortality rates from chronic diseases among cigarette smokers did not occur, primarily, because of a major adjustment in smoking intensity and depth of inhalation by the habitual smokers.
The protective role of selenium on genetic damage and on cancer.
- K. El-Bayoumy
- BiologyMutation research
- 18 April 2001
Molecular chemoprevention by selenium: a genomic approach.
- K. El-Bayoumy, R. Sinha
- BiologyMutation research
- 11 December 2005
Apoptosis is a critical cellular event in cancer chemoprevention and chemotherapy by selenium compounds.
- R. Sinha, K. El-Bayoumy
- Biology, ChemistryCurrent Cancer Drug Targets
- 31 January 2004
Several novel synthetic organoselenium compounds need to be examined both in vitro and in vivo for their potential to induce apoptosis; such an investigation may provide better and mechanism-based cancer chemoprevention as well as chemotherapeutic agents.
Identification of benzo[a]pyrene metabolites in cervical mucus and DNA adducts in cervical tissues in humans by gas chromatography-mass spectrometry.
- A. Melikian, P. Sun, S. Waggoner
- Medicine, BiologyCancer Letters
- 15 November 1999
Mechanisms of mammary cancer chemoprevention by organoselenium compounds.
- K. El-Bayoumy, R. Sinha
- Chemistry, BiologyMutation research
- 13 July 2004
Ploidy differences between hormone‐ and chemical carcinogen–induced rat mammary neoplasms: Comparison to invasive human ductal breast cancer *
- Jonathan J. Li, D. Papa, SaraAntonia Li
- BiologyMolecular Carcinogenesis
- 1 January 2002
Results clearly demonstrate that the female ACI rat E2‐induced MGTs more closely resemble invasive human DCIS and ductal BC in two pertinent aspects: they are highly aneuploid compared with chemical carcinogen–induced M GTs and exhibit a high frequency of c‐myc amplification.
Effects of 1,4-phenylenebis(methylene)selenocyanate, phenethyl isothiocyanate, indole-3-carbinol, and d-limonene individually and in combination on the tumorigenicity of the tobacco-specific…
- K. El-Bayoumy, P. Upadhyaya, D. Desai, S. Amin, D. Hoffmann, E. Wynder
- Chemistry, BiologyAnticancer Research
- 1 September 1996
Although the effect of the mixture on lung tumor incidence in this assay remained imperfect, this preliminary investigation provides some basis for the future design of chemoprevention studies.
Comparative tumorigenicity of benzo[a]pyrene, 1-nitropyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine administered by gavage to female CD rats.
- K. El-Bayoumy, Y. Chae, S. Hecht
- BiologyCarcinogenesis
- 1 February 1995
The carcinogenic activity of PhIP, given by gavage, in the mammary gland of CD rats is described and the carcinogenic potency observed under identical conditions, of three agents (B[a]P congruent to PhIP > 1-NP) that are prevalent in the human environment are ranked.
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenicity in mouse lung by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate.
- K. El-Bayoumy, P. Upadhyaya, D. Desai, S. Amin, S. Hecht
- Biology, ChemistryCarcinogenesis
- 1 June 1993
The results of this study clearly indicate that the structure of selenium-containing compounds is important in determining their efficacy as chemopreventive agents.
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