Mixed descending- and ascending-type thin limbs of Henle's loop in mammalian renal inner medulla.

@article{Pannabecker2000MixedDA,
  title={Mixed descending- and ascending-type thin limbs of Henle's loop in mammalian renal inner medulla.},
  author={Thomas L Pannabecker and Anke Dahlmann and Olga H. Brokl and William H. Dantzler},
  journal={American journal of physiology. Renal physiology},
  year={2000},
  volume={278 2},
  pages={
          F202-8
        },
  url={https://api.semanticscholar.org/CorpusID:25630851}
}
Discontinuous axial expression of AQP1, UT-A2, and ClC-K1 along the straight portion of single thin limbs indicates that these nephrons possess a more heterogeneous structure than previously recognized.
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    American journal of physiology. Renal physiology
  • 2002
It is concluded that the descending thin limbs shift from expressing AQP1 to expressing ClC-K1 some distance before the point where they turn and begin to ascend, which could have implications for the urine-concentrating mechanism.

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Diuretic state affects ascending thin limb tight junctions.

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Three-dimensional reconstruction of the mouse nephron.

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23 References

Structural differences in thin limbs of Henle: physiological implications.

Ulastructural studies suggest that the degree of passive ion permeation across epithelia may be determined by the depth of their occluding junctions, and suggest type I cell junctions may be more permeable than type II.

Structural-functional correlation in chinchilla long loop of Henle thin limbs: a novel papillary subsegment.

The ultrastructural characteristics of thin limb subsegments from chinchilla long loops of Henle were studied in perfusion-fixed kidneys and in isolated perfused tubules to identify types I, II, III, and IV thin limb epithelia similar to those previously identified in other rodent species.

In vitro perfusion of chinchilla thin limb segments: segmentation and osmotic water permeability.

New approaches to the identification, dissection, and in vitro perfusion of individual thin limb segments from all levels of the chinchilla renal medulla, including the deepest portions of the papilla are presented.

Aquaporin-1 water channels in short and long loop descending thin limbs and in descending vasa recta in rat kidney.

AQP-1 expression in DTL segments is in exact concordance with the known water permeability characteristics, strongly supporting that AQP- 1 is the major constitutive water channel of the nephron.

Segmental localization of urea transporter mRNAs in rat kidney.

R reverse transcription-polymerase chain reaction studies in microdissected structures using UT1- and UT2-specific primers indicate that these transporters play central roles in the urinary concentrating mechanism.

Amino acid fluxes in rat thin limb segments of Henle's loop during in vitro microperfusion.

The data suggest that regulation of amino acid movement in vivo may involve the vasa recta, not the DTL of Henle's loops, and suggest that transepithelial movement of amino acids in thin limbs ofHenle's loop may occur via a paracellular route.

Localization and induction by dehydration of ClC-K chloride channels in the rat kidney.

Results demonstrate that rat kidney ClC-K channels are predominantly located in the basolateral membranes from cells of the late segments of the renal tubule where most of chloride reabsorption takes place.

Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice.

It is demonstrated that AQP1 is the principal water channel in TDLH and support the view that osmotic equilibration alongTDLH by water transport plays a key role in the renal countercurrent concentrating mechanism.

Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla.

Localization and functional characterization of rat kidney-specific chloride channel, ClC-K1.

The localization and the functional characteristics described here indicate that ClC-K1 is responsible for the transepithelial chloride transport in tAL, which has the highest chloride permeability among nephron segments.