Localization and functional characterization of rat kidney-specific chloride channel, ClC-K1.

@article{Uchida1995LocalizationAF,
  title={Localization and functional characterization of rat kidney-specific chloride channel, ClC-K1.},
  author={Shunya Uchida and Sei Sasaki and Kosaku Nitta and Kohsuke Uchida and Shoko Horita and Hiroshi Nihei and Fumiaki Marumo},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={95 1},
  pages={104-13}
}
To investigate the physiological role of a kidney-specific chloride channel (ClC-K1), we sought to determine its exact localization by immunohistochemistry and its functional regulation using Xenopus oocyte expression system. The antiserum specifically recognized a 70-kD protein in SDS-PAGE of membrane protein from rat inner medulla and an in vitro translated ClC-K1 protein. Immunohistochemistry revealed that ClC-K1 was exclusively localized to the thin limb of Henle's loop in rat inner medulla… CONTINUE READING
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