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Molecular Cloning and Characterization of a Channel-like Transporter Mediating Intestinal Calcium Absorption*
TLDR
The properties of a calcium transport protein (CaT1) cloned from rat duodenum using an expression cloning strategy in Xenopus laevis oocytes are reported, which likely plays a key role in the intestinal uptake of calcium. Expand
Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney.
TLDR
Northern blot analysis and in situ hybridization indicate that these transporters are expressed predominantly in kidney with an intrarenal distribution consistent with their recognized functional localization, establishing a new family of Na(+)-(K+)-Cl- cotransporters. Expand
Molecular Characterization of a Broad Selectivity Neutral Solute Channel*
TLDR
The expression cloning of a liver cDNA encoding a unique promiscuous solute channel (AQP9) that confers high permeability for both solute and water is reported, defining a new evolutionary branch of the major intrinsic protein family of aquaporin proteins and describing a previously unknown mechanism by which a large variety of solutes and water can pass through a single pore. Expand
Molecular cloning and characterization of the vasopressin-regulated urea transporter of rat kidney collecting ducts.
TLDR
The data show that UT1 corresponds to the previously characterized vasopressin-regulated urea transporter in the apical membrane of the terminal IMCD which plays a critical role in renal water conservation. Expand
Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease.
TLDR
It is shown that PC2 is a Ca(2+)-permeable cation channel with properties distinct from any known intracellular channels, and that it can be translocated to the plasma membranes by defined chemical chaperones and proteasome modulators, suggesting that in vivo, it may also function in the plasma membrane under specific conditions. Expand
Functional roles of histidine and tyrosine residues in the H(+)-peptide transporter PepT1.
TLDR
It is proposed that H57 and H121 are intimately involved in the binding of the coupling ion H(+) and the recognition of transportable peptide substrates, respectively. Expand
Human calcium transport protein CaT1.
TLDR
A role for hCaT1 in cellular calcium uptake in a variety of tissues, including the transcellular calcium transport pathway in intestine, is suggested. Expand
CaT1 expression correlates with tumor grade in prostate cancer.
TLDR
This work reports that the gene for CaT1, a channel protein highly selective for Ca(2+), is expressed at high levels in human PCa and in the LNCaP PCa cell line, and suggests thatCaT1 may be a novel target for therapy. Expand
Molecular Characteristics of Na+-coupled Glucose Transporters in Adult and Embryonic Rat Kidney *
TLDR
It is shown that expression of rat SGLT2 mRNA is kidney specific and that it is strongly and exclusively expressed in proximal tubule S1 segments, which strongly indicate that S GLT2 is the major kidney cortical low affinity glucose transporter. Expand
Comparative analysis of glutamate transporter expression in rat brain using differential double in situ hybridization
TLDR
It is demonstrated, using a novel differential double hybridization protocol, that the presence of GLT1 mRNA in neurons is more widespread than previously thought, and that it encompasses the majority of neurons in the neocortex. Expand
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