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Physiology of the renal medullary microcirculation.
TLDR
These and other features show that vasa recta have physiological mechanisms specific to their role in the renal medulla, and suggest that other events, in addition to membrane depolarization, are needed to maximize vasoconstriction.
Aquaporin-1 water channels in short and long loop descending thin limbs and in descending vasa recta in rat kidney.
TLDR
AQP-1 expression in DTL segments is in exact concordance with the known water permeability characteristics, strongly supporting that AQP- 1 is the major constitutive water channel of the nephron.
How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension.
TLDR
Recent evidence is summarized that defines specific molecular links between Na(+) and the elevated vascular resistance that directly produces high BP, and several central and peripheral mechanisms are coordinated by EO to effect and maintain the salt-induced elevation of BP.
The renal medullary microcirculation.
TLDR
The large number of hormones and autacoids that influence DVR vasomotion, however, suggests that DVR have evolved to optimize the functions of the renal medulla.
Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse.
TLDR
The present studies suggest that the organized subcellular distribution of the NHERF isoforms may play a role in the specific interactions mediating physiological control of transporter function.
Transport of sodium and urea in outer medullary descending vasa recta.
TLDR
Electron microscopic examination of seven in vitro perfused OMVR revealed no fenestrations and exposure of these vessels to 10 microM calcium ionophore A23187 or 1 nM angiotensin II resulted in reversible contraction, suggesting that in vitro performed OMVR are DVR only.
Pericyte Regulation of Renal Medullary Blood Flow
TLDR
Oxygen tensions in the medulla are low, so that subtle variation of pericyte vasomotion might play a role to abrogate hypoxia and prevent insult to the medullary thick ascending limb of Henle.
Renal medullary microcirculation.
TLDR
The large number of hormones and autacoids that influence DVR vasomotion, however, suggests that DVR have evolved to optimize the functions of the renal medulla.
ANG II signaling in vasa recta pericytes by PKC and reactive oxygen species.
TLDR
It is concluded that ANG II and PKC activation increases DVR pericyte [Ca(2+)](cyt), divalent ion conductance into the cytoplasm, and ROS generation.
Prostaglandin E2 abrogates endothelin-induced vasoconstriction in renal outer medullary descending vasa recta of the rat.
TLDR
It is concluded thatET-1,2, and 3 are potent constrictors of OMDVR and the response to ET-1 is mainly ETA receptor subtype mediated, while ET-3 acts via the ETB.
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