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Physiology of the renal medullary microcirculation.
Perfusion of the renal medulla plays an important role in salt and water balance. Pericytes are smooth muscle-like cells that impart contractile function to descending vasa recta (DVR), theExpand
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Aquaporin-1 water channels in short and long loop descending thin limbs and in descending vasa recta in rat kidney.
The localization of aquaporin-1 water channels (AQP-1) in nephron and vascular structures in rat kidney were characterized, because vascular bundles are known to play a key role in urinaryExpand
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How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension.
Excess dietary salt is a major cause of hypertension. Nevertheless, the specific mechanisms by which salt increases arterial constriction and peripheral vascular resistance, and thereby raises bloodExpand
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Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse.
  • J. Wade, J. Liu, +6 authors E. Weinman
  • Biology, Medicine
  • American journal of physiology. Cell physiology
  • 13 August 2003
In expression systems and in yeast, Na/H exchanger regulatory factor (NHERF)-1 and NHERF-2 have been demonstrated to interact with the renal brush border membrane proteins NHE3 and Npt2. In renalExpand
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The renal medullary microcirculation.
Blood flow to the renal medulla is supplied through descending vasa recta (DVR), which are derived from the efferent arterioles of juxtamedullary glomeruli. In addition to their role as conduits forExpand
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Transport of sodium and urea in outer medullary descending vasa recta.
We dissected and perfused outer medullary vasa recta (OMVR) from vascular bundles in the rat. Permeabilities of sodium (PNa) and urea (Pu) were simultaneously determined from the lumen-to-bath effluxExpand
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Pericyte Regulation of Renal Medullary Blood Flow
Pericytes are contractile smooth muscle-like cells that surround descending vasa recta (DVR) and provide their capability for vasomotion. The importance of the medullary pericyte derives from theExpand
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Renal medullary microcirculation.
Blood flow to the renal medulla is supplied through descending vasa recta (DVR), which are derived from the efferent arterioles of juxtamedullary glomeruli. In addition to their role as conduits forExpand
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Interstitial water and solute recovery by inner medullary vasa recta.
A recent model of volume and solute microvascular exchange in the renal medulla was extended by simulating the deposition of NaCl, urea, and water into the medullary interstitium from the loops ofExpand
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Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta.
Deletion of AQP1 in mice results in diminished urinary concentrating ability, possibly related to reduced NaCl- and urea gradient-driven water transport across the outer medullary descending vasaExpand
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