Physiology of the renal medullary microcirculation.
- T. Pallone, Zhong Zhang, K. Rhinehart
- BiologyAJP - Renal Physiology
- 1 February 2003
These and other features show that vasa recta have physiological mechanisms specific to their role in the renal medulla, and suggest that other events, in addition to membrane depolarization, are needed to maximize vasoconstriction.
How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension.
- M. Blaustein, F. Leenen, W. Wier
- BiologyAmerican Journal of Physiology. Heart and…
- 1 March 2012
Recent evidence is summarized that defines specific molecular links between Na(+) and the elevated vascular resistance that directly produces high BP, and several central and peripheral mechanisms are coordinated by EO to effect and maintain the salt-induced elevation of BP.
Aquaporin-1 water channels in short and long loop descending thin limbs and in descending vasa recta in rat kidney.
- S. Nielsen, T. Pallone, B. Smith, E. Christensen, P. Agre, A. B. Maunsbach
- BiologyAmerican Journal of Physiology
- 1 June 1995
AQP-1 expression in DTL segments is in exact concordance with the known water permeability characteristics, strongly supporting that AQP- 1 is the major constitutive water channel of the nephron.
The renal medullary microcirculation.
- A. Edwards, E. P. Silldforff, T. Pallone
- BiologyFrontiers in Bioscience
- 1 July 1990
The large number of hormones and autacoids that influence DVR vasomotion, however, suggests that DVR have evolved to optimize the functions of the renal medulla.
Pericyte Regulation of Renal Medullary Blood Flow
- T. Pallone, E. Silldorff
- BiologyNephron Experimental Nephrology
- 23 April 2001
Oxygen tensions in the medulla are low, so that subtle variation of pericyte vasomotion might play a role to abrogate hypoxia and prevent insult to the medullary thick ascending limb of Henle.
Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse.
- J. Wade, Jie Liu, E. Weinman
- BiologyAmerican Journal of Physiology - Cell Physiology
- 13 August 2003
The present studies suggest that the organized subcellular distribution of the NHERF isoforms may play a role in the specific interactions mediating physiological control of transporter function.
Transport of sodium and urea in outer medullary descending vasa recta.
- T. Pallone, J. Work, R. Myers, R. Jamison
- BiologyJournal of Clinical Investigation
- 1994
Electron microscopic examination of seven in vitro perfused OMVR revealed no fenestrations and exposure of these vessels to 10 microM calcium ionophore A23187 or 1 nM angiotensin II resulted in reversible contraction, suggesting that in vitro performed OMVR are DVR only.
Renal medullary microcirculation.
- T. Pallone, C. Robertson, R. Jamison
- BiologyPhysiological Reviews
- 1 June 2000
The large number of hormones and autacoids that influence DVR vasomotion, however, suggests that DVR have evolved to optimize the functions of the renal medulla.
Iodixanol, constriction of medullary descending vasa recta, and risk for contrast medium-induced nephropathy.
- M. Sendeski, A. Patzak, T. Pallone, Chunhua Cao, A. Persson, P. Persson
- Medicine, BiologyRadiology
- 1 June 2009
Iodixanol in doses typically used for coronary interventions constricts DVR, intensifies angiotensin II-induced constriction, and reduces bioavailability of NO and scavenging of reactive oxygen species might exert a therapeutic benefit by preventing the adverse effects that a CM has on medullary perfusion.
Countercurrent exchange in the renal medulla.
- T. Pallone, M. R. Turner, A. Edwards, R. Jamison
- BiologyAmerican Journal of Physiology. Regulatory…
- 1 May 2003
DVR are vasoactive, arteriolar microvessels that are anatomically positioned to regulate total and regional blood flow to the outer and inner medulla, and recent discoveries show that transcellular as well as paracellular pathways are involved in equilibration of DVR plasma with the interstitium.
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