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Molecular Characterization of a Broad Selectivity Neutral Solute Channel*
In all living cells, coordination of solute and water movement across cell membranes is of critical importance for osmotic balance. The current concept is that these processes are of distinctExpand
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Molecular cloning and characterization of the vasopressin-regulated urea transporter of rat kidney collecting ducts.
Absorption of urea in the renal inner medullary collecting duct (IMCD) contributes to hypertonicity in the medullary interstitium which, in turn, provides the osmotic driving force for waterExpand
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Cloning and characterization of the urea transporter UT3: localization in rat kidney and testis.
Urea transport in the kidney plays an important role in urinary concentration and nitrogen balance. Recently, three types of urea transporters have been cloned, UT1 and UT2 from rat and rabbit kidneyExpand
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Novel AE1 mutations in recessive distal renal tubular acidosis. Loss-of-function is rescued by glycophorin A.
The AE1 gene encodes band 3 Cl-/HCO3- exchangers that are expressed both in the erythrocyte and in the acid-secreting, type A intercalated cells of the kidney. Kidney AE1 contributes to urinaryExpand
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Characterization of a Rat Na+-Dicarboxylate Cotransporter*
The metabolism of Krebs cycle intermediates is of fundamental importance for eukaryotic cells. In the kidney, these intermediates are transported actively into epithelial cells. Because citrate is aExpand
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Cloning and characterization of a potassium-coupled amino acid transporter.
Active solute uptake in bacteria, fungi, plants, and animals is known to be mediated by cotransporters that are driven by Na+ or H+ gradients. The present work extends the Na+ and H+ dogma byExpand
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Molecular characteristics of mammalian and insect amino acid transporters: implications for amino acid homeostasis.
In mammalian cells, the uptake of amino acids is mediated by specialized, energy-dependent and passive transporters with overlapping substrate specificities. Most energy-dependent transporters areExpand
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Segmental localization of urea transporter mRNAs in rat kidney.
Renal epithelia express at least two distinct urea transporter mRNAs, termed UT1 and UT2, that are derived from a single UT gene by alternative splicing. Previous immunolocalization studies using aExpand
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Autosomal Dominant Distal Renal Tubular Acidosis Is Associated in Three Families with Heterozygosity for the R589H Mutation in the AE1 (Band 3) Cl−/HCO3 −Exchanger*
Distal renal tubular acidosis (dRTA) is characterized by defective urinary acidification by the distal nephron. Cl−/HCO3 − exchange mediated by the AE1 anion exchanger in the basolateral membrane ofExpand
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Molecular characterization of a novel urea transporter from kidney inner medullary collecting ducts.
In the terminal part of the kidney collecting duct, rapid urea reabsorption is essential to maintaining medullary hypertonicity, allowing maximal urinary concentration to occur. This process isExpand
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