• Publications
  • Influence
Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection.
In patients with chronic HCV-1b infection, there is a substantial correlation between responses to interferon and mutations in the NS5A gene. Expand
Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region.
HCV genotype-1b with the prototypeinterferon sensitivity determining region appears to be interferon-resistant strains, and the specific nature of these mutations might make it possible to predict prognostic effects ofInterferon treatment. Expand
Cloning and expression of apical membrane water channel of rat kidney collecting tubule
The functional expression and the limited localization of WCH-CD to the apical region of the kidney collecting tubule suggest that W CH-CD is the vasopressin-regulated water channel. Expand
Localization and functional characterization of rat kidney-specific chloride channel, ClC-K1.
The localization and the functional characteristics described here indicate that ClC-K1 is responsible for the transepithelial chloride transport in tAL, which has the highest chloride permeability among nephron segments. Expand
Involvement of PYK2 in angiotensin II signaling of vascular smooth muscle cells.
Data suggest that the AT1 receptor uses Ca2+-dependent PYK2 to activate c-Src, thereby leading to EGFR transactivation, which preponderantly recruits Grb2 in rat VSMC. Expand
Phosphorylation of Serine 256 Is Required for cAMP-dependent Regulatory Exocytosis of the Aquaporin-2 Water Channel*
  • K. Fushimi, Sei Sasaki, F. Marumo
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 6 June 1997
It is indicated that serine 256 of AQP2 is necessary for regulatory exocytosis and that cAMP-responsive redistribution of AQ p2 may be regulated by phosphorylation of AQp2. Expand
Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla.
The main site of expression in kidney was the thin ascending limb of Henle's loop, which has the highest Cl- permeability among the nephron segments and is thought to be involved in a counter-current system for urine concentration in the inner medulla. Expand
Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol.
A new member (AQP9) of the aquaporin family was identified from human leukocytes by homology cloning using PCR, suggesting a unique permeability character and may expand the understanding of water and small solute transport in the body. Expand
Urinary excretion of aquaporin-2 in patients with diabetes insipidus.
Aquaporin-2 is detectable in the urine, and changes in the urinary excretion of this protein can be used as an index of the action of vasopressin on the kidney. Expand
Titin mutations as the molecular basis for dilated cardiomyopathy.
Observations suggest that titin mutations may cause DCM in a subset of the patients, and one of them was a nonsense mutation presumably encoding for a truncated nonfunctional molecule. Expand