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Regulation of epithelial shunt conductance by the peptide leucokinin
SummaryIsolated Malpighian tubules of the yellow fever mosquito Aedes aegypti spontaneously secrete NaCl, KCl and water across an epithelium of modest transepithelial resistance (40–80 Ωcm2) and highExpand
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Dibutyryl cAMP activates bumetanide-sensitive electrolyte transport in Malpighian tubules.
The effects of dibutyryl adenosine 3',5'-cyclic monophosphate (DBcAMP) and bumetanide (both 10(-4) M) on transepithelial Na+, K+, Cl-, and fluid secretion and on tubule electrophysiology were studiedExpand
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Three-dimensional architecture of inner medullary vasa recta.
The manner in which vasa recta function and contribute to the concentrating mechanism depends on their three-dimensional relationships to each other and to tubular elements. We have examined theExpand
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Leucokinins, a new family of ion transport stimulators and inhibitors in insect Malpighian tubules.
Leucokinins are octapeptides isolated from heads of the cockroach Leucophaea maderae. In the cockroach they increase motility of the isolated hindgut. Surprisingly, synthetic leucokinins haveExpand
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Three-dimensional functional reconstruction of inner medullary thin limbs of Henle's loop.
Digital three-dimensional (3-D) functional reconstructions of inner medullary nephrons were performed. Antibodies against aquaporins (AQP)-1 and -2 and the chloride channel ClC-K1 identifiedExpand
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Three-dimensional lateral and vertical relationships of inner medullary loops of Henle and collecting ducts.
Functional reconstruction of inner medullary thin limbs of Henle and collecting ducts (CDs) has enabled us to characterize distinctive three-dimensional vertical and lateral relationships betweenExpand
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Central role of the apical membrane H+-ATPase in electrogenesis and epithelial transport in Malpighian tubules.
The effects of bafilomycin A(1), a blocker of V-type H(+)-ATPases, were investigated in Malpighian tubules of Aedes aegypti. Bafilomycin A(1) reduced rates of transepithelial fluid secretion and theExpand
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Architecture of kangaroo rat inner medulla: segmentation of descending thin limb of Henle's loop.
We hypothesize that the inner medulla of the kangaroo rat Dipodomys merriami, a desert rodent that concentrates its urine to more than 6,000 mosmol/kgH(2)O water, provides unique examples ofExpand
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Tetraethylammonium block of water flux in Aquaporin-1 channels expressed in kidney thin limbs of Henle's loop and a kidney-derived cell line.
BackgroundAquaporin-1 (AQP1) channels are constitutively active water channels that allow rapid transmembrane osmotic water flux, and also serve as cyclic-GMP-gated ion channels. TetraethylammoniumExpand
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