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vatalanib

Known as: 1-(4-chloroanilino)-4-(pyridylmethyl)phthalazine, N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine, PTK/ZK 
An orally bioavailable anilinophthalazine with potential antineoplastic activity. Vatalanib binds to and inhibits the protein kinase domain of… Expand
National Institutes of Health

Papers overview

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2012
2012
INTRODUCTION The Cancer and Leukemia Group B (CALGB) conducted a multi-center phase II trial to evaluate the efficacy and safety… Expand
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Highly Cited
2011
Highly Cited
2011
PURPOSE The Colorectal Oral Novel therapy For the Inhibition of angiogenesis and Retarding of Metastases (CONFIRM)-randomized… Expand
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2009
2009
BACKGROUND This study determined the maximum tolerated dose (MTD) and dose-limiting toxicities (DLT) of the oral vascular… Expand
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2009
2009
Halting tumor growth by interfering with tumor-induced angiogenesis is an attractive therapeutic approach. Such treatments… Expand
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2008
2008
PURPOSE To analyze whether tyrosine kinase inhibitors blocking VEGF receptors (PTK787/ZK222584 [PTK/ZK] and ZK261991 [ZK991]) can… Expand
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Review
2007
Review
2007
Glioma has been considered resistant to chemotherapy and radiation. Recently, concomitant and adjuvant chemoradiotherapy with… Expand
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Review
2007
Review
2007
The prognosis of patients with glioblastoma, anaplastic astrocytoma, and anaplastic oligodendroglioma remains poor despite… Expand
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Review
2007
Review
2007
The licensing of bevacizumab in patients with metastatic colorectal cancer has fueled research in angiogenesis. Vatalanib (PTK787… Expand
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Review
2006
Review
2006
In randomized phase III trials two anti-vascular endothelial growth factor (VEGF) approaches have yielded survival benefit in… Expand
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2004
2004
The process of neoangiogenesis is induced by several mediators. Vascular endothelial growth factor (VEGF) plays a key role in… Expand
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