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Phthalazines

Known as: Phthalazines [Chemical/Ingredient] 
National Institutes of Health

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1,2,3,4-tetrahydrophthalazine1,2-dihydrophthalazine1-hydroxyphthalazine3-hydrazinethieno(2,3-h)cinnoline
In Bloodagonistsantagonists & inhibitorsaspects of radiation effects

Papers overview

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Highly Cited
2019
Highly Cited
2019
Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and acetylcholinesterase inhibitors.
2018
2018
Design, Synthesis, In Vitro Anti-cancer Activity, ADMET Profile and Molecular Docking of Novel Triazolo[3,4-a]phthalazine Derivatives Targeting VEGFR-2 Enzyme.
BACKGROUND Extensive studies were reported in the synthesis of several phthalazine derivatives as promising anticancer agents as… 
Highly Cited
2017
Highly Cited
2017
CF3SO2X (X = Na, Cl) as reagents for trifluoromethylation, trifluoromethylsulfenyl-, -sulfinyl- and -sulfonylation. Part 1: Use of CF3SO2Na
Sodium trifluoromethanesulfinate, CF3SO2Na, and trifluoromethanesulfonyl chloride, CF3SO2Cl, are two popular reagents that are… 
2017
2017
In silico molecular docking studies of new potential 4-phthalazinyl-hydrazones on selected Trypanosoma cruzi and Leishmania enzyme targets.
Highly Cited
2016
Highly Cited
2016
1-Piperazinylphthalazines as potential VEGFR-2 inhibitors and anticancer agents: Synthesis and in vitro biological evaluation.
Review
2012
Review
2012
Some recent approaches of biologically active substituted pyridazine and phthalazine drugs.
Nitrogen atom containing heterocyclic compounds, pyridazines, pyridazinones and phthalazines are important structural feature of… 
2007
2007
Iptycene-derived pyridazines and phthalazines.
The synthesis of new heterocyclic oligo(phenylene) analogues based on soluble, nonaggregating 1,2-diazines is reported. Improved… 
2005
2005
A Convenient access to thienyl‐substituted phthalazines
Thanks are due to Foundation for Science and Technology (Portugal) for financial support through IBQF (UM) and through FEDER… 
Highly Cited
1998
Highly Cited
1998
4-Benzylamino-1-chloro-6-substituted phthalazines: synthesis and inhibitory activity toward phosphodiesterase 5.
We synthesized various 4-benzylamino-1-chloro-6-substituted phthalazines (15) and 4-benzylamino-1-chloro-7-substituted… 
Highly Cited
1995
Highly Cited
1995
Substrate specificity of human liver aldehyde oxidase toward substituted quinazolines and phthalazines: a comparison with hepatic enzyme from guinea pig, rabbit, and baboon.
Partially purified aldehyde oxidase (EC 1.2.3.1) has been prepared from human, rabbit, guinea pig, and baboon liver by heat… 
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