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Receptor Tyrosine Kinase Inhibition

Known as: Tyrosine Kinase Receptor Inhibition 
A process that negatively regulates the intracellular catalytic activities that originate with the binding of a tyrosine kinase-associated… 
National Institutes of Health

Related topics

Related topics

50 relations
AXL Inhibitor BGB324Allosteric Bcr-Abl Tyrosine Kinase Inhibitor ABL001BMS 599626BMS 777607

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies
Drug resistance is a major factor that limits the efficacy of targeted cancer therapies. In this review, we discuss the main… 
2013
2013
Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region
Significance The receptor tyrosine kinase KIT is aberrantly activated primarily by somatic mutations in gastrointestinal stromal… 
Highly Cited
2006
Highly Cited
2006
Methylnaltrexone inhibits opiate and VEGF-induced angiogenesis: role of receptor transactivation.
Highly Cited
2005
Highly Cited
2005
Enhanced susceptibility of irradiated tumor vessels to vascular endothelial growth factor receptor tyrosine kinase inhibition.
Previous experiments with PTK787/ZK222584, a specific inhibitor of vascular endothelial growth factor receptor (VEGFR) tyrosine… 
Highly Cited
2004
Highly Cited
2004
BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia
Intermittent hypoxia causes a form of serotonin-dependent synaptic plasticity in the spinal cord known as phrenic long-term… 
Highly Cited
2004
Highly Cited
2004
Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Represses Cyclin D1 in Aerodigestive Tract Cancers
Purpose: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are active in cancer therapy. Mechanisms… 
Highly Cited
2004
Highly Cited
2004
Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats.
BACKGROUND Advances in the understanding of cystogenesis, identification of the PKHD1 gene and availability of a rat model (the… 
Highly Cited
2003
Highly Cited
2003
EGF receptor tyrosine kinase inhibition attenuates the development of PKD in Han:SPRD rats.
BACKGROUND Increasing evidence supports an important role for the epidermal growth factor (EGF)/transforming growth factor-alpha… 
Highly Cited
2003
Highly Cited
2003
Epidermal growth factor receptor tyrosine kinase inhibition augments a murine model of pulmonary fibrosis.
The inappropriate regeneration of sequentially injured epithelium is an important process leading to pulmonary fibrosis. Previous… 
Highly Cited
2002
Highly Cited
2002
Effect of epidermal growth factor receptor tyrosine kinase inhibition on epithelial proliferation in normal and premalignant breast.
The factors controlling epithelial proliferation in ductal carcinoma in situ (DCIS) are unclear. Antiestrogens are effective in… 
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