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AXL Inhibitor BGB324

Known as: BGB324 
An orally available and selective inhibitor of the AXL receptor tyrosine kinase (UFO), with potential antineoplastic activity. Upon administration… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2013-2017
024620132017

Related topics

Related topics

1 relation
Receptor Tyrosine Kinase Inhibition

Related mentions per year

Related mentions per year

1990-2018
1990200020102020
AXL Inhibitor BGB324
Receptor Tyrosine Kinase Inhibition

Papers overview

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2017
2017
Axl Blockade by BGB324 Inhibits BCR-ABL Tyrosine Kinase Inhibitor-Sensitive and -Resistant Chronic Myeloid Leukemia.
Purpose: BCR-ABL kinase inhibitors are employed successfully for chronic myeloid leukemia (CML) treatment. However, resistant… (More)
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2017
2017
LncRNA HOTAIR regulates HIF-1α/AXL signaling through inhibition of miR-217 in renal cell carcinoma
Long non-coding RNA HOTAIR was regarded as an oncogene in multiple cancers. Previous studies have shown that HOTAIR is involved… (More)
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2017
2017
Cisplatin and Pemetrexed Activate AXL and AXL Inhibitor BGB324 Enhances Mesothelioma Cell Death from Chemotherapy
Reactive oxygen species (ROS) can promote or inhibit tumorigenesis. In mesothelioma, asbestos exposure to serous membranes… (More)
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2017
2017
P002 Inhibition of Axl signaling by BGB324 reduces fibrogenesis in human intestinal cells and human intestinal organoids.
 
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2017
2017
Decitabine-Vorinostat combination treatment in acute myeloid leukemia activates pathways with potential for novel triple therapy
Despite advancements in cancer therapeutics, acute myeloid leukemia patients over 60 years old have a 5-year survival rate of… (More)
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2015
2015
Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells
Glioblastoma multiforme (GBM) often features a combination of tumour suppressor gene inactivation and multiple oncogene… (More)
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2015
2015
Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation.
BACKGROUND & AIMS Liver fibrosis, an important health concern associated to chronic liver injury that provides a permissive… (More)
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2015
2015
Axl inhibition: a potential road to a novel acute myeloid leukemia therapy?
Novel treatment options in acute myeloid leukemia (AML) are urgently needed; treatment has not changed significantly over the… (More)
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2015
2015
A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics
Pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related deaths in the United States, and is… (More)
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2014
2014
The role of AXL and the in vitro activity of the receptor tyrosine kinase inhibitor BGB324 in Ewing sarcoma
New targets for Ewing sarcoma (ES) patients are urgently needed. Therefore, we investigated the expression and genetic… (More)
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