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BMS 777607
Known as:
BMS-777607
, BMS777607
, MET Tyrosine Kinase Inhibitor BMS-777607
An inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor BMS-777607 binds to c-Met protein, or…
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National Institutes of Health
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Related topics
Related topics
1 relation
Receptor Tyrosine Kinase Inhibition
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer.
Canan Kasikara
,
Viralkumar Davra
,
+10 authors
R. Birge
Cancer Research
2019
Corpus ID: 80617632
Tyro3, Axl, and Mertk (TAM) represent a family of homologous tyrosine kinase receptors known for their functional role in…
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Review
2019
Review
2019
Therapeutic Inducers of Apoptosis in Ovarian Cancer
Mudra Binju
,
Monica Angelica Amaya-Padilla
,
Graeme Wan
,
Hendra Gunosewoyo
,
Y. Suryo Rahmanto
,
Yu Yu
Cancers
2019
Corpus ID: 208051747
Ovarian cancers remain one of the most common causes of gynecologic cancer-related death in women worldwide. The standard…
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2016
2016
Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo
J. Onken
,
R. Torka
,
+7 authors
P. Vajkoczy
OncoTarget
2016
Corpus ID: 7461308
Purpose Receptor tyrosine kinase AXL (RTK-AXL) is regarded as suitable target in glioma therapy. Here we evaluate the anti…
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2014
2014
Activation of HER3 interferes with antitumor effects of Axl receptor tyrosine kinase inhibitors: suggestion of combination therapy.
R. Torka
,
Kinga Pénzes
,
+5 authors
A. Ullrich
Neoplasia
2014
Corpus ID: 22044634
2014
2014
Combined inhibition of AXL, Lyn and p130Cas kinases block migration of triple negative breast cancer cells
Kinga Pénzes
,
C. Baumann
,
+4 authors
R. Torka
Cancer Biology & Therapy
2014
Corpus ID: 12457217
Blocking the migration of metastatic cancer cells is a major goal in the therapy of cancer. The receptor tyrosine kinase AXL is…
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2013
2013
Synergistic Activities of MET/RON Inhibitor BMS-777607 and mTOR Inhibitor AZD8055 to Polyploid Cells Derived from Pancreatic Cancer and Cancer Stem Cells
J. Zeng
,
Sharad K Sharma
,
+4 authors
Ming-Hai Wang
Molecular Cancer Therapeutics
2013
Corpus ID: 24510152
Tyrosine kinase inhibitor BMS-777067 is an inhibitor of RON/MET receptor tyrosine kinases currently under clinical trials. Here…
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2013
2013
Small-Molecule Inhibitor BMS-777607 Induces Breast Cancer Cell Polyploidy with Increased Resistance to Cytotoxic Chemotherapy Agents
Sharad K Sharma
,
J. Zeng
,
+5 authors
Ming-Hai Wang
Molecular Cancer Therapeutics
2013
Corpus ID: 2147079
The RON receptor tyrosine kinase is a therapeutic target for cancer treatment. Here, we report therapeutic effect and phenotypic…
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2013
2013
Inhibitors of the TAM subfamily of tyrosine kinases: synthesis and biological evaluation.
R. M. Suárez
,
Franciane Chevot
,
+6 authors
M. Legraverend
European journal of medicinal chemistry
2013
Corpus ID: 31305328
Highly Cited
2010
Highly Cited
2010
BMS-777607, a Small-Molecule Met Kinase Inhibitor, Suppresses Hepatocyte Growth Factor–Stimulated Prostate Cancer Metastatic Phenotype In vitro
Yao Dai
,
D. Siemann
Molecular Cancer Therapeutics
2010
Corpus ID: 20302879
Most prostate cancer–related deaths are due to advanced disease with patients with metastatic prostate cancer having a 5-year…
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Highly Cited
2009
Highly Cited
2009
Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of…
G. M. Schroeder
,
Yongmi An
,
+28 authors
R. Borzilleri
Journal of Medicinal Chemistry
2009
Corpus ID: 1219166
Substituted N-(4-(2-aminopyridin-4-yloxy)-3-fluoro-phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamides were…
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