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The Role of Polymeric Immunoglobulin Receptor in Inflammation-Induced Tumor Metastasis of Human Hepatocellular Carcinoma
Background Expression of the polymeric immunoglobulin receptor (pIgR), a transporter of polymeric IgA and IgM, is commonly increased in response to viral or bacterial infections, linking innate andExpand
Polymeric immunoglobulin receptor promotes tumor growth in hepatocellular carcinoma
Deregulation of the immune system is believed to contribute to cancer malignancy, which has led to recent therapeutic breakthroughs facilitating antitumor immunity. In a malignant setting,Expand
Trigochinins A-C: three new daphnane-type diterpenes from Trigonostemon chinensis.
Three highly oxygenated new diterpenes, trigochinins A-C (1-3) were isolated from Trigonostemon chinensis. Their structures with the absolute configuration were determined by a spectroscopic method,Expand
The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc
  • Caihua Zhu, Qin Chen, +4 authors M. Geng
  • Biology, Medicine
  • Journal of Molecular Medicine
  • 1 March 2011
Histone deacetylases (HDACs) play fundamental roles in the epigenetic regulation of gene expression and contribute to the growth, differentiation, and apoptosis of cancer cells. Although HDACs areExpand
Diketopiperazine alkaloids from a mangrove rhizosphere soil derived fungus Aspergillus effuses H1-1.
Effusin A (1), a spirobicyclic N,O-acetal derivative with an unprecedented 3',3a',5',6'-tetrahydrospiro[piperazine-2,2'-pyrano[2,3,4-de]chromene] ring system, and a spiro-polyketide-diketopiperazineExpand
Prenylated indole diketopiperazines from the marine-derived fungus Aspergillus versicolor.
Seven new prenylated indole diketopiperazines, versicamides A-G (1-7) and a novel chemical derivative from 7, versicamide H (8), along with three known analogic diketopiperazines (9-11) were obtainedExpand
Synthesis and c-Met kinase inhibition of 3,5-disubstituted and 3,5,7-trisubstituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a
  • Yuanxiang Wang, Jing Ai, +5 authors A. Zhang
  • Medicine, Chemistry
  • Journal of medicinal chemistry
  • 15 March 2011
By use of an improved synthetic strategy, a series of 3,5-disubstituted and 3,5,7-trisubstituted quinolines were readily prepared. 3,5,7-Trisubstituted quinolines 21a-c, 21l, and 27a-c wereExpand
Design, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffold.
  • Jian Liu, X. Peng, +5 authors Yingxia Li
  • Chemistry, Medicine
  • Organic & biomolecular chemistry
  • 8 July 2015
Fibroblast growth factor receptor (FGFR) is a potential target for cancer therapy. Based on the structure of AZD4547 and NVPBGJ-398, we designed novel 1H-indazol-3-amine scaffold derivatives byExpand
α2,6-hyposialylation of c-Met abolishes cell motility of ST6Gal-I-knockdown HCT116 cells
Aim:We aimed to investigate the potential modification of previously unrecognized surface glycoprotein(s) by α2,6-sialylation other than by integrins.Methods:The expression of β-galactosideExpand
Novel carbon-bridged citrinin dimers from a volcano ash-derived fungus Penicillium citrinum and their cytotoxic and cell cycle arrest activities
Abstract Three novel carbon-bridged citrinin dimers, dicitrinones A–C ( 1 – 3 ), were isolated from a volcano ash-derived fungus Penicillium citrinum . Their structures were elucidated byExpand