The Role of Polymeric Immunoglobulin Receptor in Inflammation-Induced Tumor Metastasis of Human Hepatocellular Carcinoma
- Jing Ai, Qingjuan Tang, M. Geng
- Medicine, BiologyJournal of the National Cancer Institute
- 24 October 2011
High expression of pIgR was statistically significantly associated with early recurrence in early-stage HCC and in hepatitis B surface antigen–positive HCC patients and was sufficient to induce EMT through activation of Smad signaling.
Prenylated indole diketopiperazines from the marine-derived fungus Aspergillus versicolor.
Seven new prenylated indole diketopiperazines, versicamides A-G and a novel chemical derivative from 7, Versicamide H (8), along with three known analogic diktopiperazine (9-11) were obtained from the marine-derived fungus Aspergillus versicolor HDN08-60 and exhibited selective PTK inhibitory activities.
Polymeric immunoglobulin receptor promotes tumor growth in hepatocellular carcinoma
The molecular mechanism by which pIgR promotes cancer malignancy is revealed, the clinical potential of targeting this pathway in HCC is suggested, and new insight is provided into the oncogenic role of immunoglobulin receptors.
Trigochinins A-C: three new daphnane-type diterpenes from Trigonostemon chinensis.
This study suggested the revision of the C-6 stereochemistry of trigonothyrins A-C reported quite recently, which showed significant inhibition against MET tyrosine kinase activity.
The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc
It is reported that HDAC7 is a crucial player in cancer cell proliferation and an unrecognized link betweenHDAC7 and c-Myc is highlighted for the first time and a novel mechanistic insight into the contribution of HDAC 7 to tumor progression is offered.
Novel carbon-bridged citrinin dimers from a volcano ash-derived fungus Penicillium citrinum and their cytotoxic and cell cycle arrest activities
Design, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffold.
Structural optimization revealed that compound 7r stood out as the most potent FGFR1 inhibitor with the best enzyme inhibitory and cellular activity and the crystal structure of 7n bound toFGFR1 might provide a new basis for potent inhibitor design.
Synthesis and c-Met kinase inhibition of 3,5-disubstituted and 3,5,7-trisubstituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a…
Results clearly indicated that compound 21b is a potent and highly selective c-Met inhibitor and its favorable in vitro and in vivo profiles warrant further investigation.
α2,6-hyposialylation of c-Met abolishes cell motility of ST6Gal-I-knockdown HCT116 cells
The hyposialylation of c-Met can abolish cell motility in ST6Gal-I-KD HCT116 cells, and this selectively altered cell migration was caused by the loss of α2,6-sialic acid structures on c- met.
Design and optimization of a series of 1-sulfonylpyrazolo[4,3-b]pyridines as selective c-Met inhibitors.
- Yu-chi Ma, Guangqiang Sun, Jing-kang Shen
- Chemistry, BiologyJournal of Medicinal Chemistry
- 25 February 2015
On the basis of in vitro and in vivo pharmacological and pharmacokinetics studies, compound 46 was selected as a preclinical candidate for further anticancer drug development.