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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.
TLDR
Amplification of the HER-2/neu gene was a significant predictor of both overall survival and time to relapse in patients with breast cancer, and had greater prognostic value than most currently used prognostic factors in lymph node-positive disease.
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer.
TLDR
The concept that the HER-2/neu gene may be involved in the pathogenesis of some human cancers, including breast and ovarian cancer, is supported.
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TLDR
The transactivation of epidermal growth factor receptor (EGFR)-dependent signalling pathways upon stimulation of G-protein-coupled receptors (GPCRs) provides evidence for an interconnected communication network and establishes a new mechanistic concept for cross-communication among different signalling systems.
Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
TLDR
It is reported here that the epidermal growth factor receptor (EGFR) and the neu oncoprotein become rapidly tyrosine-phosphorylated upon stimulation of Rat-1 cells with the GPCR agonists endothelin-1, lysophosphatic acid and thrombin, suggesting that there is an intracellular mechanism for transactivation.
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close
Signal characteristics of G protein‐transactivated EGF receptor
TLDR
The results demonstrate an essential role for EGFR function in signaling through both Gq‐ and Gi‐coupled receptors and provide novel insights into signal transmission downstream of EGFR for efficient activation of the Ras/MAPK pathway.
The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification.
TLDR
A broad overview of signal transduction networks that are controlled by the EGFR superfamily of receptors in health and disease and its application for target-selective therapeutic intervention is given.
A family of proteins that inhibit signalling through tyrosine kinase receptors
TLDR
The findings indicate that proteins belonging to the SIRP family generally regulate signals defining different physiological and pathological processes.
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