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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.
The HER-2/neu oncogene is a member of the erbB-like oncogene family, and is related to, but distinct from, the epidermal growth factor receptor. This gene has been shown to be amplified in humanExpand
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer.
Carcinoma of the breast and ovary account for one-third of all cancers occurring in women and together are responsible for approximately one-quarter of cancer-related deaths in females. The HER-2/neuExpand
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
Cross-communication between different signalling systems allows the integration of the great diversity of stimuli that a cell receives under varying physiological situations. The transactivation ofExpand
Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
TRANSDUCTION of a mitogenic signal from the cell membrane to the nucleus involves the adapter proteins SHC and Grb2, which mediate activation of the Ras/mitogen-activated protein (MAP) kinaseExpand
Signal transduction by receptors with tyrosine kinase activity
Cet article synthese montre comment des recepteurs membranaires a activite tyrosine kinase peuvent etre impliques dans la transduction et notamment jouent le role de signal de la transduction
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals closeExpand
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
Examination of flk-1 receptor tyrosine kinase mRNA expression by in situ hybridization analysis revealed specific association with endothelial cells at all stages of mouse development, including theExpand
Signal characteristics of G protein‐transactivated EGF receptor
The epidermal growth factor receptor (EGFR) tyrosine kinase recently was identified as providing a link to mitogen‐activated protein kinase (MAPK) in response to G protein‐coupled receptor (GPCR)Expand
The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification.
Homeostasis of multicellular organisms is critically dependent on the correct interpretation of the plethora of signals which cells are exposed to during their lifespan. Various soluble factorsExpand
The discovery of receptor tyrosine kinases: targets for cancer therapy
Receptor tyrosine kinases are a subclass of cell-surface growth-factor receptors with an intrinsic, ligand-controlled tyrosine-kinase activity. They regulate diverse functions in normal cells andExpand