• Publications
  • Influence
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer.
TLDR
The addition of cetuximab to capecitabine, oxaliplatin, and bevacizumab resulted in significantly shorter progression-free survival and inferior quality of life. Expand
Shared and separate functions of polo-like kinases and aurora kinases in cancer
TLDR
It is becoming clear that interplay between polo-like kinases and aurora kinases is much more extensive than initially anticipated, and that both kinase families are important factors in the response to classical chemotherapeutics that damage the genome or the mitotic spindle. Expand
Symptom prevalence in patients with incurable cancer: a systematic review.
TLDR
The results of this study should be used to guide doctors and nurses in symptom management and should be the basis for individually tailored treatment aimed at improving or maintaining quality of life of patients in their last period of life. Expand
Inhibition of angiogenesis in vivo by interleukin 12.
TLDR
It is suggested that IL 12 may possess antiangiogenic properties that account for its tumor-inhibitory effects in vivo, and its mechanisms may be crucial in planning its clinical applications, including a possibility of coadministration with other inhibitors of neovascularization. Expand
Genetic analysis of von Hippel‐Lindau disease
TLDR
A comprehensive mutation table of 1,548 germline and somatic VHL mutations, derived from this protein of only 213 amino acids is compiled, intended to facilitate research and function as a necessary adjunct for physicians when providing patient information. Expand
Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents.
TLDR
It is shown that certain chemotherapy drugs, e.g., paclitaxel, can rapidly induce proangiogenic bone marrow-derived circulating endothelial progenitor (CEP) mobilization and subsequent tumor homing, whereas others do not. Expand
Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo.
TLDR
It is concluded that ROIs increase VEGF gene expression in vitro and during the reperfusion of ischemic retina in vivo and the ROI-associated increases are mediated largely through increases in V EGF mRNA stability. Expand
A model of angiogenesis in the mouse cornea.
TLDR
This noninflammatory model of corneal neovascularization is especially advantageous because it is reproducible, economical, and facilitates investigation of angiogenesis in various murine tumor models as well as in genetically defined murine strains. Expand
Increased levels of viable circulating endothelial cells are an indicator of progressive disease in cancer patients.
TLDR
In progressive cancer patients, the amount of circulating endothelial cells (CECs) is increased and these CECs are viable and may contribute to vessel formation, which is influenced by anticancer treatment. Expand
American Society of Clinical Oncology perspective: Raising the bar for clinical trials by defining clinically meaningful outcomes.
TLDR
This monograph presents a meta-analyses of the immune system’s response to chemotherapy and some of the mechanisms leading to cell reprograming, as well as a review of existing studies and some new literature on the use of chemotherapy to correct for these problems. Expand
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