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PTK 787

Known as: PTK-787, PTK787 
 
National Institutes of Health

Papers overview

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2012
2012
PURPOSE Angiogenesis is a key process in tumor progression. By binding VEGF, VEGF receptor-2 (VEGFR2) is a main signaling… Expand
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2012
2012
BACKGROUND AND PURPOSE The potent pro-angiogenic growth factors VEGF-A and basic fibroblast growth factor (bFGF) exert their… Expand
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2011
2011
PURPOSE Inhibition of angiogenesis has shown clinical success in patients with cancer. Thus, imaging approaches that allow for… Expand
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2009
2009
BACKGROUND This study determined the maximum tolerated dose (MTD) and dose-limiting toxicities (DLT) of the oral vascular… Expand
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Review
2007
Review
2007
Glioma has been considered resistant to chemotherapy and radiation. Recently, concomitant and adjuvant chemoradiotherapy with… Expand
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2005
2005
BACKGROUND Perivascular inflammation and subsequent smooth muscle cell (SMC) proliferation are central in the development of… Expand
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2005
2005
OBJECTIVES/HYPOTHESIS Vascular endothelial growth factor (VEGF) is an important mediator in tumor vascularization, growth, and… Expand
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Review
2005
Review
2005
The treatment of lung cancer remains a significant challenge. Although chemotherapy remains the standard approach, a plateau has… Expand
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Highly Cited
2003
Highly Cited
2003
OBJECTIVE Hepatocyte growth factor/scatter factor (HGF/SF) promotes vascular endothelial growth factor (VEGF) expression and… Expand
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2000
2000
The sprouting of new blood vessels, or angiogenesis, is necessary for any solid tumor to grow large enough to cause life… Expand
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