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PTK 787

Known as: PTK-787, PTK787 
National Institutes of Health

Related topics

Related topics

5 relations
CGP79787DPTK787/ZK 222584ZK 222584

Broader (2)

Vatalanib Succinatevatalanib

Papers overview

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2013
2013
Synthesis and biological evaluation of substituted 1,2,3-benzotriazines and pyrido[3,2-d]-1,2,3-triazines as inhibitors of vascular endothelial growth factor receptor-2.
2012
2012
Indolinones and anilinophthalazines differentially target VEGF‐A‐ and basic fibroblast growth factor‐mediated responses in primary human endothelial cells
BACKGROUND AND PURPOSE The potent pro‐angiogenic growth factors VEGF‐A and basic fibroblast growth factor (bFGF) exert their… 
2011
2011
In-Vivo Visualization of Tumor Microvessel Density and Response to Anti-Angiogenic Treatment by High Resolution MRI in Mice
Purpose Inhibition of angiogenesis has shown clinical success in patients with cancer. Thus, imaging approaches that allow for… 
2009
2009
Growth inhibition by tyrosine kinase inhibitors in mesothelioma cell lines.
2007
2007
Inhibition of vascular endothelial growth factor receptor tyrosine kinases impairs adipose tissue development in mouse models of obesity.
Review
2005
Review
2005
Targeting angiogenesis with vascular endothelial growth factor receptor small-molecule inhibitors: novel agents with potential in lung cancer.
The treatment of lung cancer remains a significant challenge. Although chemotherapy remains the standard approach, a plateau has… 
2005
2005
Antivascular Therapy of Oral Tongue Squamous Cell Carcinoma with PTK787
Objectives/Hypothesis: Vascular endothelial growth factor (VEGF) is an important mediator in tumor vascularization, growth, and… 
2003
2003
The kinase inhibitor PKC412 suppresses epiretinal membrane formation and retinal detachment in mice with proliferative retinopathies.
PURPOSE Platelet-derived growth factor (PDGF) is an important stimulatory factor for proliferative retinopathies. Expression of… 
Review
2003
Review
2003
Current studies with PTK787, an oral inhibitor of vascular endothelial growth factor in colorectal cancer.
2000
2000
New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis.
The sprouting of new blood vessels, or angiogenesis, is necessary for any solid tumor to grow large enough to cause life… 
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