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Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization
It is reported here that deficient PAI1 expression in host mice prevented local invasion and tumor vascularization of transplanted malignant keratinocytes and this experimental evidence demonstrates that host-produced PAI is essential for cancer cell invasion and angiogenesis. Expand
Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element.
It is proposed that each of the 3.3kb elements in the partially deleted D4Z4 locus could include a DUX4 gene encoding a double homeodomain protein. Expand
Modulation of adipose tissue expression of murine matrix metalloproteinases and their tissue inhibitors with obesity.
In vitro conversion of adipogenic 3T3-F442A cells into mature adipocytes was associated with substantial modulations of MMP and TIMP expression, and this in vitro adipogenesis was reduced in the presence of a synthetic MMP inhibitor. Expand
Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
- C. Maes, P. Carmeliet, +5 authors G. Carmeliet
- Medicine, Biology
- Mechanisms of Development
- 1 September 2000
The findings indicate that expression of VEGF164 and/or V EGF188 is important for normal endochondral bone development, not only to mediate bone vascularization but also to allow normal differentiation of hypertrophic chondrocytes, osteoblasts, endothelial cells and osteoclasts. Expand
Measurement of plasminogen activator inhibitor 1 in biologic fluids with a murine monoclonal antibody-based enzyme-linked immunosorbent assay.
- P. Declerck, M. Alessi, M. Verstreken, E. Kruithof, I. Juhan-vague, D. Collen
- Biology, Medicine
The present assay, based on stable and reproducible reagents, allows the specific determination of PAI-1 antigen in biologic fluids and may facilitate interlaboratory comparisons and be useful for further investigations of the role of PAi-1 in clinical conditions associated with impaired fibrinolysis and/or a tendency to thrombosis. Expand
Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.
- M. Hoylaerts, D. Rijken, H. Lijnen, D. Collen
- Chemistry, Medicine
- The Journal of biological chemistry
- 25 March 1982
The kinetic analysis suggested that the activation in the presence of fibrin occurs through binding of an activator molecule to the clot surface and subsequent addition of plasminogen (sequential ordered mechanism) to form a cyclic ternary complex. Expand
Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli
Bacterial clones containing human tissue-type plasminogen activator cDNA sequences were identified in a cDNA library prepared using gel-fractionated mRNA from human melanoma cells and a polypeptide was produced having the fibrinolytic properties characteristic of authentic human t-PA. Expand
Hemorrhagic events during therapy with recombinant tissue-type plasminogen activator, heparin, and aspirin for acute myocardial infarction. Results of the Thrombolysis in Myocardial Infarction…
Increased morbidity due to hemorrhagic complications is associated with an invasive management strategy in patients with acute myocardial infarction and the complex interaction of several factors in the occurrence of hemorrhagic events during thrombolytic therapy is shown. Expand
The plasminogen (fibrinolytic) system.
- D. Collen
- Thrombosis and haemostasis
- 1 August 1999
The aim of the present review is to summarize the main developments in the plasminogen field since the 1980s, which has been catalyzed by the emergence of powerful molecular biological technologies, including recombinant DNA techniques for the expression of heterologous proteins and targeted gene manipulation in vivo for the elucidation of the (patho)physiological role of their translation products. Expand
Function of the plasminogen/plasmin and matrix metalloproteinase systems after vascular injury in mice with targeted inactivation of fibrinolytic system genes.
- H. Lijnen, B. van Hoef, F. Lupu, L. Moons, P. Carmeliet, D. Collen
- Biology, Medicine
- Arteriosclerosis, thrombosis, and vascular…
- 1 July 1998
The data of this study confirm a role for uPA and Plg but not for tPA in smooth muscle cell migration and neointima formation after vascular injury and indicate that impairment of these phenomena may occur despite the observed increases in M MP-2 or MMP-9 levels after vascular injuries. Expand