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tyrphostin AG 1478

Known as: AG 1478, RTKI cpd, tyrphostin-AG1478 
A member of the tyrphostin family of tyrosine kinase inhibitors, that selectively inhibits epidermal growth factor. (NCI)
National Institutes of Health

Related topics

Related topics

6 relations

Broader (5)

Benzylidene CompoundsEnzyme InhibitorsNitrilesQuinazolines
Receptor Tyrosine Kinase Inhibition

Papers overview

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Highly Cited
2007
Highly Cited
2007
The delta-opioid receptor agonist DADLE at reperfusion protects the heart through activation of pro-survival kinases via EGF receptor transactivation.
The specific delta-opioid receptor agonist [D-Ala(2)-D-Leu(5)]enkephalin (DADLE) protects against infarction in the heart when… 
Highly Cited
2007
Highly Cited
2007
A Novel Phosphoinositide 3-Kinase-dependent Pathway for Angiotensin II/AT-1 Receptor-mediated Induction of Collagen Synthesis in MES-13 Mesangial Cells*
Chronic activation of the angiotensin II (ANG II) type 1 receptor (AT-1R) is critical in the development of chronic kidney… 
Highly Cited
2004
Highly Cited
2004
Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy.
Epidermal growth factor receptor (EGFR) inhibition with small molecule tyrosine kinase inhibitors results in antitumor activity… 
Highly Cited
2004
Highly Cited
2004
Metalloproteinase-dependent Transforming Growth Factor-α Release Mediates Neurotensin-stimulated MAP Kinase Activation in Human Colonic Epithelial Cells*
Expression of the neuropeptide neurotensin (NT) and its high affinity receptor (NTR1) is increased during the course of… 
Highly Cited
2004
Highly Cited
2004
The Human Papillomavirus Type 16 E5 Protein Modulates ERK1/2 and p38 MAP Kinase Activation by an EGFR-Independent Process in Stressed Human Keratinocytes
The human papillomavirus type 16 E5 gene product has been shown to upregulate the activation of MAP kinases ERK1/2 and cellular… 
Highly Cited
2004
Highly Cited
2004
Delayed and Sustained Activation of Extracellular Signal-regulated Kinase in Human Keratinocytes by UVA
Exposure to the sun's UV radiation appears to be the most important environmental factor involved in the development of skin… 
Highly Cited
2001
Highly Cited
2001
Ouabain-induced Signaling and Vascular Smooth Muscle Cell Proliferation*
The hypothesis of this study is that the sodium pump complex acts as an intracellular signal-transducing molecule in canine… 
Highly Cited
2001
Highly Cited
2001
EGFR tyrosine kinase inhibitor AG1478 inhibits cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cells.
Highly Cited
2001
Highly Cited
2001
Activation of the EGF receptor signaling pathway in airway epithelial cells exposed to Utah Valley PM.
Exposure to ambient particulate matter (PM) in the Utah Valley has previously been associated with a variety of adverse health… 
Highly Cited
1999
Highly Cited
1999
Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells.
Increased expression of cyclooxygenase-2 (COX-2) expression has been observed in several human tumor types and in selected animal… 
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