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Nitriles

Known as: NITRILE, Nitriles [Chemical/Ingredient] 
Organic compounds containing the -CN radical. The concept is distinguished from CYANIDES, which denotes inorganic salts of HYDROGEN CYANIDE.
National Institutes of Health

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1,2,4,5-tetracyanobenzene1,2-benzenedicarbonitrile1,4-diisocyanobenzene1-butyl-3-methylimidazolium tetracyanoborate
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antagonists & inhibitorschemical synthesis

Papers overview

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Review
2016
Review
2016
Microbial enzymes: industrial progress in 21st century
Biocatalytic potential of microorganisms have been employed for centuries to produce bread, wine, vinegar and other common… Expand
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Highly Cited
2011
Highly Cited
2011
Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites*
The prodrug nifurtimox has been used for more than 40 years to treat Chagas disease and forms part of a recently approved… Expand
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Review
2010
Review
2010
Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophore.
Fraser F. Fleming,* Lihua Yao, P. C. Ravikumar, Lee Funk, and Brian C. Shook Department of Chemistry and Biochemistry, Duquesne… Expand
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Review
2006
Review
2006
Biology and biochemistry of glucosinolates.
Glucosinolates are sulfur-rich, anionic natural products that upon hydrolysis by endogenous thioglucosidases called myrosinases… Expand
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Highly Cited
2002
Highly Cited
2002
Synthetic applications of 1,3-dipolar cycloaddition chemistry toward heterocycles and natural products
Nitrones (Jason N. Martin and Raymond C. F. Jones). Nitronates (Scott E. Denmark and Jeromy J. Cottell). Azomethine Ylides (L. M… Expand
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Highly Cited
2001
Highly Cited
2001
The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and influences Trichoplusia ni herbivory.
Glucosinolates are anionic thioglucosides that have become one of the most frequently studied groups of defensive metabolites in… Expand
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Highly Cited
2001
Highly Cited
2001
Preparation of 5-substituted 1H-tetrazoles from nitriles in water.
The addition of sodium azide to nitriles to give 1H-tetrazoles is shown to proceed readily in water with zinc salts as catalysts… Expand
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Highly Cited
2001
Highly Cited
2001
Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues.
Through an effort to develop novel ligands that have subtype selectivity for the estrogen receptors alpha (ERalpha) and beta… Expand
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Review
1998
Review
1998
Metalloenzyme nitrile hydratase: Structure, regulation, and application to biotechnology
Nitrile hydratase (NHase), which catalyzes the hydration of nitriles to amides, has been used in the industrial production of… Expand
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Highly Cited
1994
Highly Cited
1994
Isolation and structure elucidation of new nitrile and mustard oil glycosides from Moringa oleifera and their effect on blood pressure.
Bioassay-guided analysis of an EtOH extract of Moringa oleifera leaves showing hypotensive activity led to the isolation of two… Expand
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