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Quinone chemistry and toxicity.
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Roles of key active-site residues in flavocytochrome P450 BM3.
The effects of mutation of key active-site residues (Arg-47, Tyr-51, Phe-42 and Phe-87) in Bacillus megaterium flavocytochrome P450 BM3 were investigated. Kinetic studies on the oxidation of laurateExpand
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Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124
Firefly luciferase (FLuc), an ATP-dependent bioluminescent reporter enzyme, is broadly used in chemical biology and drug discovery assays. PTC124 (Ataluren;Expand
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Protein targets of reactive metabolites of thiobenzamide in rat liver in vivo.
Thiobenzamide (TB) is a potent hepatotoxin in rats, causing dose-dependent hyperbilirubinemia, steatosis, and centrolobular necrosis. These effects arise subsequent to and appear to result from theExpand
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ABSORPTION AND ELIMINATION OF FORMATE FOLLOWING ORAL ADMINISTRATION OF CALCIUM FORMATE IN FEMALE HUMAN SUBJECTS
Calcium formate is a water-soluble salt of an essential mineral nutrient with potential for use as a dietary calcium supplement. Formate ion is a product of endogenous and xenobiotic metabolism, butExpand
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Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes.
The hepatotoxicity of thioacetamide (TA) has been known since 1948. In rats, single doses cause centrolobular necrosis accompanied by increases in plasma transaminases and bilirubin. To elicit theseExpand
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Relative Bioavailability of Calcium from Calcium Formate, Calcium Citrate, and Calcium Carbonate
Calcium is an essential nutrient required in substantial amounts, but many diets are deficient in calcium making supplementation necessary or desirable. The objective of this study was to compare theExpand
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A proteomic analysis of bromobenzene reactive metabolite targets in rat liver cytosol in vivo.
Metabolic activation and protein covalent binding are early and apparently obligatory events in the cytotoxicity of many simple organic chemicals including drugs and natural products. Although muchExpand
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X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives.
The mechanism of action of a general class of mechanism-based inhibitors of serine proteases, including human neutrophil elastase (HNE), has been elucidated by determining the X-ray crystal structureExpand
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A convenient reverse-phase liquid chromatographic assay for epoxide hydrase.
Abstract A rapid, convenient assay for epoxide hydrase is described. The method is based on direct analysis of quenched incubation mixtures by reverse-phase liquid chromatography, and utilizesExpand
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