A highly conserved sequence is a novel gene involved in de novo vitamin B6 biosynthesis.
- M. Ehrenshaft, P. Bilski, M. Li, C. Chignell, M. Daub
- BiologyProceedings of the National Academy of Sciences…
- 3 August 1999
It is shown that SOR1 is essential in pyridoxine (vitamin B6) synthesis in C. nicotianae and Aspergillus flavus, although it shows no homology to previously identified pyrIDoxine synthesis genes identified in Escherichia coli.
SPECTRAL AND PHOTOCHEMICAL PROPERTIES OF CURCUMIN
- C. Chignell, Piotr Bilskj, K. Reszka, A. Motten, R. Sik, T. Dahl
- ChemistryPhotochemistry and Photobiology
- 1 March 1994
Findings indicate that the spectral and photochemical properties of curcumin are strongly influenced by solvent and in biological systems, singlet oxygen, superoxide and products of photodegradation may all participate inCurcumin phototoxicity depending on the environment of the dye.
Evidence for free radical formation during the oxidation of 2'-7'-dichlorofluorescin to the fluorescent dye 2'-7'-dichlorofluorescein by horseradish peroxidase: possible implications for oxidative…
- C. Rota, C. Chignell, R. Mason
- Chemistry, BiologyFree Radical Biology & Medicine
- 1 October 1999
Cytotoxic action of juglone and plumbagin: a mechanistic study using HaCaT keratinocytes.
- J. J. Inbaraj, C. Chignell
- Biology, ChemistryChemical Research in Toxicology
- 2004
The findings indicate that topical preparations containing juglone and plumbagin should be used with care as their use may damage the skin, and it is probable that the antifungal, antiviral, and antibacterial properties of these quinones are the result of redox cycling.
Photoreduction of the fluorescent dye 2'-7'-dichlorofluorescein: a spin trapping and direct electron spin resonance study with implications for oxidative stress measurements.
- E. Marchesi, C. Rota, Y. Fann, C. Chignell, R. Mason
- ChemistryFree Radical Biology & Medicine
- 1999
Fluoroquinolone Antimicrobials: Singlet Oxygen, Superoxide and Phototoxicity
- L. Martínez, R. Sik, C. Chignell
- Biology, ChemistryPhotochemistry and Photobiology
- 1 April 1998
Although there is not a one‐to‐one correspondence between the relative rates of superoxide generation and the phototoxicity ranking of the fluoroquinolones, the more phototoxic compounds tended to produce superoxide at a faster rate.
Vitamin B6 (Pyridoxine) and Its Derivatives Are Efficient Singlet Oxygen Quenchers and Potential Fungal Antioxidants
- P. Bilski, M. Li, M. Ehrenshaft, M. Daub, C. Chignell
- ChemistryPhotochemistry and Photobiology
- 1 February 2000
Fluorescence intensity of 3 increased ∼10 times in organic solvents such as ethanol and 1,2‐propanediol compared to aqueous solutions, suggesting that fluorescence may be used to image the distribution of 1–4 in Cercospora to understand better the interactions of pyridoxine and 1O2 in the living fungus.
Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance
- Y-Y. He, J. Pi, J.-L. Huang, B. Diwan, M. Waalkes, C. Chignell
- Biology, MedicineOncogene
- 22 June 2006
It is demonstrated that chronic UVA exposures at environmentally relevant doses in vitro can induce malignant transformation of human keratinocytes associated with acquired apoptotic resistance and that the increased AKT signaling and decreased PTEN expression may contribute to thismalignant transformation.
Reaction of melatonin and related indoles with hydroxyl radicals: EPR and spin trapping investigations.
- Z. Matuszak, K. Reszka, C. Chignell
- Chemistry, BiologyFree Radical Biology & Medicine
- 1997
Delayed and Sustained Activation of Extracellular Signal-regulated Kinase in Human Keratinocytes by UVA
- Yu-Ying He, Jian-Li Huang, C. Chignell
- BiologyJournal of Biological Chemistry
- 17 December 2004
The delayed and sustained ERK activation provides a survival signal to human HaCaT keratinocytes, which may serve as an important mechanism for cell transformation and potential skin carcinogenesis in vivo caused by UVA exposure.
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