C. Chignell

Publications305
h-index52
Citations9,825
Highly Influential Citations235
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A highly conserved sequence is a novel gene involved in de novo vitamin B6 biosynthesis.
TLDR
It is shown that SOR1 is essential in pyridoxine (vitamin B6) synthesis in C. nicotianae and Aspergillus flavus, although it shows no homology to previously identified pyrIDoxine synthesis genes identified in Escherichia coli. Expand
SPECTRAL AND PHOTOCHEMICAL PROPERTIES OF CURCUMIN
TLDR
Findings indicate that the spectral and photochemical properties of curcumin are strongly influenced by solvent and in biological systems, singlet oxygen, superoxide and products of photodegradation may all participate inCurcumin phototoxicity depending on the environment of the dye. Expand
Evidence for free radical formation during the oxidation of 2'-7'-dichlorofluorescin to the fluorescent dye 2'-7'-dichlorofluorescein by horseradish peroxidase: possible implications for oxidative…
TLDR
DCF fluorescence cannot be used reliably to measure O2- in cells because O2*- itself is formed during the conversion of DCFH to DCF by peroxidases, and the use of this probe to measure H2O2 production in cells is problematic. Expand
Cytotoxic action of juglone and plumbagin: a mechanistic study using HaCaT keratinocytes.
TLDR
The findings indicate that topical preparations containing juglone and plumbagin should be used with care as their use may damage the skin, and it is probable that the antifungal, antiviral, and antibacterial properties of these quinones are the result of redox cycling. Expand
Fluoroquinolone Antimicrobials: Singlet Oxygen, Superoxide and Phototoxicity
TLDR
Although there is not a one‐to‐one correspondence between the relative rates of superoxide generation and the phototoxicity ranking of the fluoroquinolones, the more phototoxic compounds tended to produce superoxide at a faster rate. Expand
Photoreduction of the fluorescent dye 2'-7'-dichlorofluorescein: a spin trapping and direct electron spin resonance study with implications for oxidative stress measurements.
TLDR
The photoreduction of 2'-7'-dichlorofluorescein (DCF) was investigated in buffer solution using direct electron spin resonance (ESR) and the ESR spin-trapping technique to demonstrate the production of the superoxide dismutase-sensitive DMPO/*OOH adduct. Expand
Reaction of melatonin and related indoles with hydroxyl radicals: EPR and spin trapping investigations.
TLDR
The rate constants, k(r), are determined for scavenging .OH radicals by melatonin, 5-methoxytryptamine (5-MeO-T), 5-hydroxytryptamines (serotonin), 6-chloromelatonin (6-Cl-MLT, 6-hydroxymelatonin), and kynurenine (KN) in aqueous solutions. Expand
Vitamin B6 (Pyridoxine) and Its Derivatives Are Efficient Singlet Oxygen Quenchers and Potential Fungal Antioxidants
TLDR
Fluorescence intensity of 3 increased ∼10 times in organic solvents such as ethanol and 1,2‐propanediol compared to aqueous solutions, suggesting that fluorescence may be used to image the distribution of 1–4 in Cercospora to understand better the interactions of pyridoxine and 1O2 in the living fungus. Expand
Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance
TLDR
It is demonstrated that chronic UVA exposures at environmentally relevant doses in vitro can induce malignant transformation of human keratinocytes associated with acquired apoptotic resistance and that the increased AKT signaling and decreased PTEN expression may contribute to thismalignant transformation. Expand
Enhanced photodynamic efficacy towards melanoma cells by encapsulation of Pc4 in silica nanoparticles.
TLDR
The results show that these stable, monodispersed silica nanoparticles may be an effective new formulation for Pc4 in its preclinical and clinical studies and expect that modifying the surface of silicon nanoparticles encapsulating the photosensitizers with antibodies specific to melanoma cells will lead to even better early diagnosis and targeted treatment of melanoma in the future. Expand
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