FAQ

tyrphostin 25

Known as: 4,5-Trihydroxybenzylidene malononitrile, Tyrphostin A25, tyrphostin-25 
A member of the tyrphostin family of tyrosine kinase inhibitors that competitively binds and inhibits epidermal growth factor receptor and GTPase… (More)

Topic mentions per year

Topic mentions per year

1992-2016
0102019922016

Related topics

Related topics

5 relations

Broader (4)

Antineoplastic AgentsEnzyme InhibitorsNitrilesTyrphostins
Receptor Tyrosine Kinase Inhibition

Related mentions per year

Related mentions per year

1944-2018
19401960198020002020
tyrphostin 25
Antineoplastic Agents
Enzyme Inhibitors
Nitriles
Tyrphostins
Receptor Tyrosine Kinase Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway.
Fibronectin fragments (FN-f), including the 110-kDa fragment that binds the alpha5beta1 integrin, stimulate collagenase-3 (MMP-13… (More)
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Highly Cited
2000
Highly Cited
2000
Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments.
Programmed cell death comprises several subtypes, as revealed by electron microscopy. Apoptosis or type I programmed cell death… (More)
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1998
1998
Constitutively active Galpha12, Galpha13, and Galphaq induce Rho-dependent neurite retraction through different signaling pathways.
In neuronal cells, activation of a certain heterotrimeric G protein-coupled receptor causes neurite retraction and cell rounding… (More)
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1998
1998
Tyrosine kinase inhibitor effects on avian osteoclastic acid transport.
We found that tyrosine kinase pp60(c-src) coisolates with acid-transporting osteoclast membranes and hypothesized that this… (More)
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1997
1997
Inhibition of epidermal growth factor receptor-associated tyrosine kinase blocks glioblastoma invasion of the brain.
OBJECTIVE Glioblastoma multiforme is a malignant primary brain tumor associated with short patient survival despite aggressive… (More)
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1996
1996
Substance P-induced mitogenesis in human astrocytoma cells correlates with activation of the mitogen-activated protein kinase signaling pathway.
The neuropeptide substance P (SP) regulates many biological processes through binding to and activating the SP receptor (NK-1… (More)
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Highly Cited
1996
Highly Cited
1996
Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells.
Genistein is a naturally occurring dietary protein tyrosine kinase (PTK) inhibitor that is hypothesized to be responsible for the… (More)
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1996
1996
Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strain.
The objective of this study was to determine whether focal adhesion proteins pp125FAK (focal adhesion kinase) and paxillin are… (More)
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1996
1996
Variable effects of tyrosine kinase inhibitors on avian osteoclastic activity and reduction of bone loss in ovariectomized rats.
We compared the effects of the tyrosine kinase inhibitor genistein, a naturally occurring isoflavone, to those of tyrphostin A25… (More)
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1994
1994
Multiple actions of epidermal growth factor and TGF-alpha on rabbit gastric parietal cell function.
Parietal cells in primary culture and freshly isolated parietal cells were used to compare acute and chronic effects of epidermal… (More)
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