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tyrphostin 25

Known as: 4,5-Trihydroxybenzylidene malononitrile, Tyrphostin A25, tyrphostin-25 
A member of the tyrphostin family of tyrosine kinase inhibitors that competitively binds and inhibits epidermal growth factor receptor and GTPase… Expand
National Institutes of Health

Related topics

Related topics

5 relations

Broader (4)

Antineoplastic AgentsEnzyme InhibitorsNitrilesTyrphostins
Receptor Tyrosine Kinase Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Perivascular adipose tissue promotes vasoconstriction: the role of superoxide anion.
OBJECTIVES Recent studies have demonstrated that perivascular adipose tissue (PVAT) releases vascular relaxation factor(s). In… Expand
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Highly Cited
2004
Highly Cited
2004
Mechanisms of ADRF release from rat aortic adventitial adipose tissue.
Blood vessels are surrounded by variable amounts of adipose tissue. We showed earlier that adventitial adipose tissue inhibits… Expand
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Highly Cited
2003
Highly Cited
2003
Fibronectin Fragment Activation of Proline-rich Tyrosine Kinase PYK2 Mediates Integrin Signals Regulating Collagenase-3 Expression by Human Chondrocytes through a Protein Kinase C-dependent Pathway*
Fibronectin fragments (FN-f), including the 110-kDa fragment that binds the α5β1 integrin, stimulate collagenase-3 (MMP-13… Expand
Highly Cited
2000
Highly Cited
2000
Intestinal trefoil factor confers colonic epithelial resistance to apoptosis.
Intestinal trefoil factor (ITF) is an essential regulator of colonic epithelial restitution, the rapid migration of colonocytes… Expand
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Highly Cited
2000
Highly Cited
2000
Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments.
Programmed cell death comprises several subtypes, as revealed by electron microscopy. Apoptosis or type I programmed cell death… Expand
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Highly Cited
1996
Highly Cited
1996
Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells.
Genistein is a naturally occurring dietary protein tyrosine kinase (PTK) inhibitor that is hypothesized to be responsible for the… Expand
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Highly Cited
1996
Highly Cited
1996
Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strain.
The objective of this study was to determine whether focal adhesion proteins pp125FAK (focal adhesion kinase) and paxillin are… Expand
Highly Cited
1996
Highly Cited
1996
Substance P-induced mitogenesis in human astrocytoma cells correlates with activation of the mitogen-activated protein kinase signaling pathway.
The neuropeptide substance P (SP) regulates many biological processes through binding to and activating the SP receptor (NK-1… Expand
Highly Cited
1994
Highly Cited
1994
Tyrosine kinase inhibitors attenuate "capacitative" Ca2+ influx in rat pancreatic acinar cells.
The effect of several tyrosine kinase inhibitors was tested on Ca2+ influx mediated by thapsigargin-and CCh-induced intracellular… Expand
Highly Cited
1993
Highly Cited
1993
Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation
The effect of the isoflavones, genistein, daidzein, and biochanin A on the growth of the LNCaP and DU‐145 human prostate cancer… Expand
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