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Tyrphostins

Known as: Tyrphostins [Chemical/Ingredient], tyrphostin 
A family of synthetic protein tyrosine kinase inhibitors. They selectively inhibit receptor autophosphorylation and are used to study receptor… Expand
National Institutes of Health

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Highly Cited
2003
Highly Cited
2003
Estradiol (E2) rapidly stimulates signal transduction from plasma membrane estrogen receptors (ER) that are G protein-coupled… Expand
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Highly Cited
1998
Highly Cited
1998
Adhesion of human primary skin fibroblasts and ECV304 endothelial cells to immobilized matrix proteins, β1 or αv integrin… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND The gene Sry acts as a developmental switch, initiating a pathway of gene activity that leads to the differentiation… Expand
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Highly Cited
1996
Highly Cited
1996
TRANSDUCTION of a mitogenic signal from the cell membrane to the nucleus involves the adapter proteins SHC and Grb2, which… Expand
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Highly Cited
1996
Highly Cited
1996
A series of 3-indoleacrylonitrile tyrphostins, 2-chloro-3-phenylquinolines, and 3-arylquinoxalines were prepared and tested for… Expand
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Highly Cited
1991
Highly Cited
1991
We have previously described a novel series of low molecular weight protein tyrosine kinase inhibitors which we named tyrphostins… Expand
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Review
1990
Review
1990
  • A. Levitzki
  • Biochemical pharmacology
  • 1990
  • Corpus ID: 3074836
Le but de cette etude est de developper un bloqueur selectif des proteines oncogenes intervenant dans les phenomenes de… Expand
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Highly Cited
1989
Highly Cited
1989
A novel class of low molecular weight protein tyrosine kinase inhibitors is described. These compounds constitute a systematic… Expand
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Highly Cited
1989
Highly Cited
1989
Synthetic compounds called tyrphostins were examined for their effects on cells which are mitogenically responsive to epidermal… Expand
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Highly Cited
1989
Highly Cited
1989
Binding of EGF to cells expressing human EGF receptor stimulated rapid tyrosine phosphorylation of phospholipase C-II (PLC-II… Expand
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