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Tyrphostins

Known as: Tyrphostins [Chemical/Ingredient], tyrphostin 
A family of synthetic protein tyrosine kinase inhibitors. They selectively inhibit receptor autophosphorylation and are used to study receptor… 
National Institutes of Health

Related topics

Related topics

38 relations

Narrower (30)

4-nitrobenzylidene malononitrile6,7-dimethoxy-3-phenylquinoxalineAG 127AG 30

Broader (2)

Antineoplastic AgentsEnzyme Inhibitors
In Bloodagonistsantagonists & inhibitorsaspects of radiation effects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Targeting the IGF1 axis in cancer proliferation
The IGF network of ligands, cell-surface receptors and IGF-binding proteins has important roles at multiple levels, including the… 
Highly Cited
2006
Highly Cited
2006
Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase.
Highly Cited
2006
Highly Cited
2006
Airway hyper‐responsiveness in allergic asthma in guinea‐pigs is mediated by nerve growth factor via the induction of substance P: a potential role for trkA
Background: The neurotrophin nerve growth factor (NGF) has been implicated as a mediator in allergic asthma. Direct evidence that… 
Highly Cited
2002
Highly Cited
2002
Tyrphostins Protect Neuronal Cells from Oxidative Stress*
Tyrphostins are a family of tyrosine kinase inhibitors originally synthesized as potential anticarcinogenic compounds. Because… 
Highly Cited
2001
Highly Cited
2001
Role of leptin in ulcer healing.
Highly Cited
2001
Highly Cited
2001
EGF receptor-ERK pathway is the major signaling pathway that mediates upregulation of aldose reductase expression under oxidative stress.
Highly Cited
1999
Highly Cited
1999
Tyrphostin AG‐490 inhibits cytokine‐mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen‐activated human T cells
Janus kinase 3 (JAK3) is a cytoplasmic tyrosine kinase required for T cell development and activated by cytokines that utilize… 
Highly Cited
1995
Highly Cited
1995
Tyrosine kinase phosphorylation of GABAA receptors.
Highly Cited
1993
Highly Cited
1993
Inhibition of bradykinin- and thapsigargin-induced Ca2+ entry by tyrosine kinase inhibitors.
Highly Cited
1992
Highly Cited
1992
Epigenetic role of epidermal growth factor expression and signalling in embryonic mouse lung morphogenesis.
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