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Tyrphostins

Known as: Tyrphostins [Chemical/Ingredient], tyrphostin 
A family of synthetic protein tyrosine kinase inhibitors. They selectively inhibit receptor autophosphorylation and are used to study receptor… 
National Institutes of Health

Related topics

Related topics

38 relations

Narrower (30)

4-nitrobenzylidene malononitrile6,7-dimethoxy-3-phenylquinoxalineAG 127AG 30

Broader (2)

Antineoplastic AgentsEnzyme Inhibitors
In Bloodagonistsantagonists & inhibitorsaspects of radiation effects

Papers overview

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Highly Cited
2012
Highly Cited
2012
Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight.
Sixteen flavonoids and related compounds have been tested for their ability to inhibit three acidophilic Ser/Thr protein kinases… 
Highly Cited
1996
Highly Cited
1996
Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins.
A series of 3-indoleacrylonitrile tyrphostins, 2-chloro-3-phenylquinolines, and 3-arylquinoxalines were prepared and tested for… 
Highly Cited
1995
Highly Cited
1995
Activation of the small GTP-binding proteins rho and rac by growth factor receptors.
The small GTP-binding proteins, rho and rac, control signal transduction pathways that link growth factor receptors to the… 
Highly Cited
1994
Highly Cited
1994
Ultraviolet B injury increases prostaglandin synthesis through a tyrosine kinase-dependent pathway. Evidence for UVB-induced epidermal growth factor receptor activation.
Highly Cited
1993
Highly Cited
1993
Inhibition of bradykinin- and thapsigargin-induced Ca2+ entry by tyrosine kinase inhibitors.
Review
1992
Review
1992
Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction
Protein tyrosine kinases (PTKs) are members of a growing family of oncoproteins and protooncoproteins that play a pivotal role in… 
Highly Cited
1992
Highly Cited
1992
Epigenetic role of epidermal growth factor expression and signalling in embryonic mouse lung morphogenesis.
Highly Cited
1991
Highly Cited
1991
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
We have previously described a novel series of low molecular weight protein tyrosine kinase inhibitors which we named tyrphostins… 
Highly Cited
1989
Highly Cited
1989
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.
A novel class of low molecular weight protein tyrosine kinase inhibitors is described. These compounds constitute a systematic… 
Highly Cited
1989
Highly Cited
1989
EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling
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