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Tyrphostins

Known as: Tyrphostins [Chemical/Ingredient], tyrphostin 
A family of synthetic protein tyrosine kinase inhibitors. They selectively inhibit receptor autophosphorylation and are used to study receptor… Expand
National Institutes of Health

Papers overview

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Review
2006
Review
2006
The development of tyrosine phosphorylation inhibitors has transformed the approach to cancer therapy and is likely to affect… Expand
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Highly Cited
2003
Highly Cited
2003
Estradiol (E2) rapidly stimulates signal transduction from plasma membrane estrogen receptors (ER) that are G protein-coupled… Expand
Highly Cited
1998
Highly Cited
1998
Adhesion of human primary skin fibroblasts and ECV304 endothelial cells to immobilized matrix proteins, β1 or αv integrin… Expand
Highly Cited
1997
Highly Cited
1997
BACKGROUND The gene Sry acts as a developmental switch, initiating a pathway of gene activity that leads to the differentiation… Expand
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Highly Cited
1996
Highly Cited
1996
TRANSDUCTION of a mitogenic signal from the cell membrane to the nucleus involves the adapter proteins SHC and Grb2, which… Expand
Review
1992
Review
1992
  • A. Levitzki
  • FASEB journal : official publication of the…
  • 1992
  • Corpus ID: 20857955
Protein tyrosine kinases (PTKs) are members of a growing family of oncoproteins and protooncoproteins that play a pivotal role in… Expand
Highly Cited
1991
Highly Cited
1991
We have previously described a novel series of low molecular weight protein tyrosine kinase inhibitors which we named tyrphostins… Expand
Highly Cited
1989
Highly Cited
1989
A novel class of low molecular weight protein tyrosine kinase inhibitors is described. These compounds constitute a systematic… Expand
Highly Cited
1989
Highly Cited
1989
Binding of EGF to cells expressing human EGF receptor stimulated rapid tyrosine phosphorylation of phospholipase C-II (PLC-II… Expand
Highly Cited
1989
Highly Cited
1989
Synthetic compounds called tyrphostins were examined for their effects on cells which are mitogenically responsive to epidermal… Expand