Skip to search formSkip to main contentSkip to account menu

Tyrphostins

Known as: Tyrphostins [Chemical/Ingredient], tyrphostin 
A family of synthetic protein tyrosine kinase inhibitors. They selectively inhibit receptor autophosphorylation and are used to study receptor… 
National Institutes of Health

Related topics

Related topics

38 relations

Narrower (30)

4-nitrobenzylidene malononitrile6,7-dimethoxy-3-phenylquinoxalineAG 127AG 30

Broader (2)

Antineoplastic AgentsEnzyme Inhibitors
In Bloodagonistsantagonists & inhibitorsaspects of radiation effects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Regulation of voltage-gated cardiac sodium current by epidermal growth factor receptor kinase in guinea pig ventricular myocytes.
Highly Cited
2006
Highly Cited
2006
Airway hyper‐responsiveness in allergic asthma in guinea‐pigs is mediated by nerve growth factor via the induction of substance P: a potential role for trkA
Background: The neurotrophin nerve growth factor (NGF) has been implicated as a mediator in allergic asthma. Direct evidence that… 
Highly Cited
2003
Highly Cited
2003
Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors.
The overexpression and/or mutation of the epidermal growth factor receptor family of tyrosine kinases, namely EGFR and HER-2… 
2002
2002
TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity.
2001
2001
Regulation of p42/p44 MAPK and p38 MAPK by the adenosine A(1) receptor in DDT(1)MF-2 cells.
Highly Cited
2001
Highly Cited
2001
Regulation of IL-13 production by histamine in cloned murine T helper type 2 cells.
1997
1997
Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase.
Highly Cited
1995
Highly Cited
1995
Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase.
Efficient replication of HIV-1 requires establishment of the proviral state, i.e., the integration of a DNA copy of the viral… 
Highly Cited
1994
Highly Cited
1994
Cytosolic Ca2+ transients are not required for platelet-derived growth factor to induce cell cycle progression of vascular smooth muscle cells in primary culture. Actions of tyrosine kinase.
Highly Cited
1994
Highly Cited
1994
Tyrphostin induced growth inhibition: correlation with effect on p210bcr-abl autokinase activity in K562 chronic myelogenous leukemia.
We have examined a series of tyrosine kinase inhibitors structurally related to erbstatin (tyrphostins) for inhibition of p210bcr… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)