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Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.
HIF-1 contributes to the epithelial-mesenchymal transition in VHL-null RCC by indirect repression of E-cadherin, a critical event in the pathogenesis of invasive and metastatic cancer. Expand
Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis.
Collectively, Artepillin C showed anti-inflammatory effects mediated, at least in part, by prostaglandin E(2) and nitric oxide inhibition through NF-kappaB modulation, and exhibited bioavailability by oral administration. Expand
Expression of Vascular Endothelial Growth Factor Receptor 1 in Bone Marrow-derived Mesenchymal Cells Is Dependent on Hypoxia-inducible Factor 1*
It is found that exposure of cultured mouse bone marrow-derived mesenchymal stromal cells (MSC) to hypoxia or an adenovirus encoding a constitutively active form of Hypoxia-inducible factor 1 (HIF-1) induced VEGFR1 mRNA and protein expression and promoted ex vivo migration in response to VEGF or PLGF. Expand
Suppression of tumor-induced angiogenesis by Brazilian propolis: major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation.
It is concluded that artepillin C at least in part is responsible for the antiangiogenic activity of EEBP in vivo and may prove useful in the development of agents and foods with therapeutic or preventive activity against tumor angiogenesis. Expand
Tumor cell alpha-N-acetylgalactosaminidase activity and its involvement in GcMAF-related macrophage activation.
Tumor-derived alpha-NaGalase is different in biochemical characterization compared to normal alpha-N-acetyl galactosaminidase from normal Chang liver cells and decreases the potency of GcMAF on macrophage activation. Expand
Gc protein (vitamin D-binding protein): Gc genotyping and GcMAF precursor activity.
In this review, the structure and function of the Gc protein is focused on especially with regard to Gc genotyping and GcMAF precursor activity. Expand
Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism.
Hydrogen transfer from artepillin C to cumylperoxyl radical proceeds via one-step hydrogen atom transfer rather than via electron transfer, the rate constant of which is comparable to that ofExpand
A mitochondria-targeted fluorescent probe for selective detection of mitochondrial labile Fe(ii).
A new mitochondria-targeted fluorescent probe for Fe(ii) based on N-oxide chemistry, which was able to detect endogenously accumulated Fe(II) induced as a result of the inhibition of heme synthesis. Expand
A highly selective turn-on fluorescent probe for iron(II) to visualize labile iron in living cells
Although labile iron plays critical roles in diverse biological processes in living cells, the physiological and pathophysiological functions of iron have not been sufficiently explored, partiallyExpand
2-Nitroimidazole-tricarbocyanine conjugate as a near-infrared fluorescent probe for in vivo imaging of tumor hypoxia.
In vivo fluorescence imaging specifically detected GPU-167 in tumors 24 h after administration and ex vivo analysis revealed that fluorescence showed a strong correlation with hypoxia inducible factor (HIF)-1 active hypoxic regions, suggesting thatGPU-167 is a promising in vivo optical imaging probe for tumor hypoxIA. Expand