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Alcoholic Liver Disease: Pathogenesis and Current Management
The fibrotic response begins with active pericellular fibrosis, which may progress to cirrhosis, characterized by excessive liver scarring, vascular alterations, and eventual liver failure. Expand
Regulation of interleukin-10 secretion by histamine in TH2 cells and splenocytes.
The pretreatment of splenocytes with histamine in the presence of anti-IL-10 abrogated histamine-mediated inhibition of IFN gamma production suggesting that the effects of histamine onIFN gamma secretion were regulated by IL-10 in multi-cell system. Expand
Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice.
A new strain of highly immunodeficient nonobese diabetic/Shi-scid /IL-2Rγc(null) (NOG) mice that carry two copies of the mouse albumin promoter-driven urokinase-type plasminogen activator transgene for dual reconstitution with human liver and immune cells are evaluated. Expand
The effects of histamine on interferon gamma production are dependent on the stimulatory signals.
The inhibitory effects of histamine were completely reversed by cimetidine in a dose-dependent manner in both TH1 cells and in splenocytes, and the role of protein kinase A in the histamine-mediated effects on IFN gamma production was evaluated. Expand
Alcoholic and non-alcoholic steatohepatitis.
The present review includes pre-clinical, translational and clinical research that characterize alcoholic liver disease (ALD) and non-alcoholic steatohepatitis (NASH) and examines the role of genetics in the development of ASH and NASH. Expand
Epigenetic regulation in alcoholic liver disease
Alcoholic liver disease (ALD) is characterized by steatosis or fat deposition in the liver and inflammation, which leads to cirrhosis and hepatocellular carcinoma. Induction of target genes withoutExpand
Treatment options for alcoholic and non-alcoholic fatty liver disease: A review
The involvement of several inter-related pathways in the pathogenesis of these diseases suggests that a single therapeutic agent is unlikely to be an effective treatment strategy, and a combination therapy towards multiple targets would eventually be required. Expand
Impaired methylation as a novel mechanism for proteasome suppression in liver cells.
In vitro exposure of cell cytosolic fractions or highly purified 20S proteasome to low SAM:S-adenosylhomocysteine (SAH) ratios in the buffer also suppressed proteasomesome function, indicating that one or more methyltransferase(s) may be associated with proteasomal subunits. Expand
Betaine Treatment Attenuates Chronic Ethanol-Induced Hepatic Steatosis and Alterations to the Mitochondrial Respiratory Chain Proteome
Protection by betaine attenuates alcoholic steatosis and alterations to the oxidative phosphorylation system, and preservation of mitochondrial function may be another key molecular mechanism responsible for betaine hepatoprotection. Expand
Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: implications for impaired immune function during disease.
The data support the notion that HIV-1 infection and EtOH may work in concert to affect immune function including antigen presentation and thereby affect disease progression. Expand