An Update on the Etiology and Epidemiology of Diabetes Mellitus
- E. Adeghate, P. Schattner, E. Dunn
- MedicineAnnals of the New York Academy of Sciences
- 1 November 2006
Since there is an increase in the trend at which diabetes prevail, it is evident that environmental factors are playing a more increasing role in the cause of diabetes mellitus.
Visfatin: structure, function and relation to diabetes mellitus and other dysfunctions.
- E. Adeghate
- Biology, MedicineCurrent Medicinal Chemistry
- 31 July 2008
Since evidence of a direct link between visfatin genotype and human type 2 diabetes mellitus is still weak, more molecular, physiological and clinical studies are needed to determine the role of visFatin in the etiology and pathogenesis of type 2abetes mellitus.
Chronic Complications of Diabetes Mellitus: A Mini Review.
- M. Lotfy, Jennifer O Adeghate, H. Kalasz, Jaipaul Singh, E. Adeghate
- Medicine, BiologyCurrent Diabetes Reviews
- 14 December 2016
Chronic complications of DM are caused largely by HG-induced cellular and molecular impairment of neural and vascular structure and function, which may lead to the dysfunction of cells, tissues and organ systems.
Evidence to suggest morphological and physiological alterations of lacrimal gland acini with ageing.
- C. Draper, E. Adeghate, J. Singh, D. Pallot
- Biology, MedicineExperimental Eye Research
- 1 March 1999
Evidence is presented to suggest that acinar cells of the lacrimal gland undergo progressive alterations with age, including a reduction in the ability of the acini to synthesise proteins with age and altered responsiveness to cholinergic stimulation to secrete proteins.
Molecular and cellular basis of the aetiology and management of diabetic cardiomyopathy: A short review
- E. Adeghate
- Medicine, BiologyMolecular and Cellular Biochemistry
- 1 June 2004
Diabetes mellitus induces abnormal pathological findings including cell hypertrophy, neuropathy, interstitial fibrosis, myocytolysis and apoptosis and lipid deposits in the heart, and Beta-adrenoreceptor antagonists, ACE inhibitors, endothelin-receptor antagonist, adrenomedullin, hormones and antioxidants reduce interstitial Fibrosis and improve cardiac function in diabetic cardiomyopathy.
Effects of Momordica charantia fruit juice on islet morphology in the pancreas of the streptozotocin-diabetic rat.
- I. Ahmed, E. Adeghate, A. Sharma, D. Pallot, J. Singh
- BiologyDiabetes Research and Clinical Practice
- 1 June 1998
The Protective Effect of Tribulus terrestris in Diabetes
- A. Amin, M. Lotfy, M. Shafiullah, E. Adeghate
- BiologyAnnals of the New York Academy of Sciences
- 1 November 2006
This investigation suggests that the protective effect of TT for STZ‐induced diabetic rats may be mediated by inhibiting oxidative stress.
GABA in the endocrine pancreas: cellular localization and function in normal and diabetic rats.
- E. Adeghate, A. Ponery
- Biology, MedicineTissue & Cell
- 1 February 2002
Findings showed that the number of GABA-LIR cells is reduced significantly in diabetes, and GABA is a strong secretagogue of insulin from the pancreas of normal rat.
Structural changes in the myocardium during diabetes-induced cardiomyopathy
- E. Adeghate, Jaipaul Singh
- Medicine, BiologyHeart Failure Reviews
- 2013
Evidence from many studies shows that both type 1 and type 2 diabetes-induced HG can cause myocardial fibrosis, mitochondriopathy, myocyte hypertrophy and deranged myofibrils, which may eventually result in HF if left untreated.
Effect of subcutaneous pancreatic tissue transplants on streptozotocin-induced diabetes in rats. III. Distribution of neuropeptides in normal and diabetic (host) pancreas.
- E. Adeghate
- Biology, MedicineTissue & Cell
- 1 February 1999
The pattern of distribution and density of NPY, SP and VIP in the pancreas of STZ-induced diabetic rats with SPTG is similar to that observed in normal Pancreas, but the expression of CGRP and CCK-8 seemed to have increased as a result of transplantation and or diabetes.
...
...