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troglitazone

Known as: 5-[[4-[4(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl\-2,4-thiazolidinedione, 5-((4-((3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy)phenyl)methyl)-2,4-Thiazolidinedione, 5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione 
An orally-active thiazolidinedione with antidiabetic and hepatotoxic properties and potential antineoplastic activity. Troglitazone activates… 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (5)

2,4-thiazolidinedioneChromansCytochrome P-450 CYP3A InducersHypoglycemic Agents

Narrower (2)

CS 045Prelay
Diabetes Mellitus, Non-Insulin-DependentDrug AllergyNCIt Antineoplastic Agent TerminologyPeroxisome Proliferator-activated Receptor alpha Agonists [MoA]

Papers overview

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2010
2010
Diabetes drugs offered fresh start
As FDA advisers vote for restrictions on Avandia, researchers reveal a way to make such drugs safer. 
2004
2004
Effect of Nuclear Factor-kappa B Inhibitors and Peroxisome Proliferator-activated Receptor-gamma Ligands on PTHrP Release from Human Fetal Membranes
M. Lappasa,*, M. Permezela, P. W. Hob, J. M. Moseleyb, M. E. Wlodekc and G. E. Ricea a Department of Obstetrics and Gynaecology… 
2001
2001
Comparison of the metabolic effects of metformin and troglitazone on fructose-induced insulin resistance in male Sprague-Dawley rats.
BACKGROUND AND PURPOSE Insulin resistance is a hallmark of the development of type 2 diabetes. Metformin and troglitazone are… 
2001
2001
Troglitazone and Liver Function Abnormalities
Objectives: To investigate whether there were any cases of liver function abnormalities possibly associated with troglitazone use… 
2001
2001
Administration of troglitazone, but not pioglitazone, reduces insulin resistance caused by short-term dexamethasone (DXM) treatment by accelerating the metabolism of DXM.
Thiazolidine derivatives are newly developed insulin sensitizer agents that act to lower plasma glucose and reduce… 
2000
2000
Effects of troglitazone on collagen accumulation and distensibility of aortic wall in prestage of non-insulin-dependent diabetes mellitus of Otsuka Long-Evans Tokushima Fatty rats.
We investigated the effect of troglitazone (TG) on aortic distensibility and histopathology at the preclinical stage in the non… 
2000
2000
Characterization of UDP-glucuronosyltransferases (UGTS) involved in the metabolism of troglitazone in rats and humans.
UDP-glucuronosyltransferases (UGTs) involved in troglitazone glucuronidation in rats and humans have been characterized to… 
2000
2000
Effects of fructose and troglitazone on phospholipid fatty acid composition in rat skeletal muscle
Skeletal muscle phospholipid fatty acid (PLFA) composition is associated with insulin sensitivity in animal models and in man… 
1999
1999
Troglitazone Inhibits Voltage-Dependent Calcium Currents in Guinea Pig Cardiac Myocytes
Background—It has been suggested that intracellular Ca2+ overload in cardiac myocytes leads to the development of diabetic… 
1995
1995
Is oxidative stress the missing link between insulin resistance and atherosclerosis?
Dear Sir, It is noteworthy that the hypotheses which have been advocated to explain the pathogenesis of cardiovascular disease…