troglitazone

Known as: 5-[[4-[4(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl\-2,4-thiazolidinedione, 5-((4-((3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy)phenyl)methyl)-2,4-Thiazolidinedione, 5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione 
An orally-active thiazolidinedione with antidiabetic and hepatotoxic properties and potential antineoplastic activity. Troglitazone activates… (More)
National Institutes of Health

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Highly Cited
2001
Highly Cited
2001
OBJECTIVES:Troglitazone is a thiazolidinedione and peroxisome proliferator–activated receptor gamma (PPARγ) ligand used to treat… (More)
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Highly Cited
2001
Highly Cited
2001
Atherosclerotic coronary heart disease is a common complication of the insulin resistance syndrome that can occur with or without… (More)
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Highly Cited
2001
Highly Cited
2001
Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a ligand-activated nuclear receptor expressed in all of the major… (More)
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Highly Cited
1998
Highly Cited
1998
Troglitazone (CS-045) is one of the thiazolidinediones that activate the peroxisome proliferator-activated receptor gamma… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Combination therapy is logical for patients with non-insulin-dependent (type 2) diabetes mellitus, because they often… (More)
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Highly Cited
1998
Highly Cited
1998
There is increasing evidence that insulin resistance may be causally related to atherosclerosis. The measurement of common… (More)
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Highly Cited
1997
Highly Cited
1997
We have investigated the antidiabetic action of troglitazone in aP2/DTA mice, whose white and brown fat was virtually eliminated… (More)
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Highly Cited
1997
Highly Cited
1997
Troglitazone is a thiazolidinedione under development for the treatment of NIDDM and potentially other insulin-resistant disease… (More)
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Highly Cited
1996
Highly Cited
1996
Vascular smooth muscle cell (VSMC) proliferation and migration are responses to arterial injury that are highly important to the… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND Troglitazone decreases insulin resistance and hyperglycemia in patients with non-insulin-dependent diabetes mellitus… (More)
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