Troglitazone treatment increases plasma vascular endothelial growth factor in diabetic patients and its mRNA in 3T3-L1 adipocytes.

@article{Emoto2001TroglitazoneTI,
  title={Troglitazone treatment increases plasma vascular endothelial growth factor in diabetic patients and its mRNA in 3T3-L1 adipocytes.},
  author={Makoto Emoto and Takatoshi Anno and Yoshihiko Sato and Katsuya Tanabe and Shigeru Okuya and Yukio Tanizawa and Akira Matsutani and Yoshitomo Oka},
  journal={Diabetes},
  year={2001},
  volume={50 5},
  pages={
          1166-70
        }
}
Troglitazone is one of the thiazolidinediones, a new class of oral antidiabetic compounds that are ligands of peroxisome proliferator-activated receptor-gamma. This study on vascular endothelial growth factor (VEGF), also known as vascular permeability factor, was prompted by our clinical observation that the characteristics of troglitazone-induced edema were very similar to those caused by vascular hyperpermeability. When Japanese diabetic patients were screened for plasma VEGF, we found… CONTINUE READING
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