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trofosfamide

Known as: N,N-3'-tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine, 2-oxide, 2-[bis(2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxaphosphorine 2-oxide, N,N,3-tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide 
An orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (4)

Antineoplastic Agents, AlkylatingCyclophosphamideImmunosuppressive AgentsMutagens

Narrower (1)

Ixoten
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Trefoil Factor 2 Requires Na/H Exchanger 2 Activity to Enhance Mouse Gastric Epithelial Repair*
Background: Trefoil factors promote tissue repair, but in vivo mechanisms are unknown. Results: Trefoil factors fail to stimulate… 
Highly Cited
2004
Highly Cited
2004
Epidermal growth factor and trefoil factor family 2 synergistically trigger chemotaxis on BEAS-2B cells via different signaling cascades.
Injured areas of the respiratory epithelium are subject to rapid repair by the migration of adjacent epithelial cells, a process… 
Highly Cited
2004
Highly Cited
2004
Trefoil factor family (TFF) peptides: regulators of mucosal regeneration and repair, and more
Highly Cited
2004
Highly Cited
2004
Immunoassays of human trefoil factors 1 and 2: measured on serum from patients with inflammatory bowel disease
Background: The trefoil factors (TFF1–3) are cysteine‐rich peptides expressed in the gastrointestinal tract where they play a… 
Highly Cited
2000
Highly Cited
2000
Synthesis and localization of the mucin-associated TFF-peptides in the human uterus
Abstract. TFF-peptides (formerly P-domain peptides, trefoil factors) are typical secretory products of mucin-producing cells and… 
Highly Cited
2000
Highly Cited
2000
Isolation and characterization of putative trefoil peptide receptors
Highly Cited
2000
Highly Cited
2000
Individualizing the aorto-radial pressure transfer function: feasibility of a model-based approach.
We fitted a three-segment transmission line model for the radial-carotid/aorta pressure transfer function (TFF) in 31 controls… 
Highly Cited
1999
Highly Cited
1999
Hepatocyte nuclear factor 3 (winged helix domain) activates trefoil factor gene TFF1 through a binding motif adjacent to the TATAA box.
The winged helix transcription factors HNF-3/FKH (forkhead homologs) activate endodermal-derived and acute-phase gene expression… 
Highly Cited
1999
Highly Cited
1999
Trefoil factor-2, human spasmolytic polypeptide, promotes branching morphogenesis in MCF-7 cells.
Members of the trefoil factor (TFF) family are highly expressed in endodermal ulcerative wound healing and selectively in… 
Highly Cited
1999
Highly Cited
1999
Secretion of TFF-peptides by human salivary glands
Abstract. TFF-peptides (formerly P-domain peptides, trefoil factors) are typical secretory products of mucin-producing cells and… 
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