trofosfamide

Known as: N,N-3'-tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine, 2-oxide, 2-[bis(2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxaphosphorine 2-oxide, N,N,3-tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide 
An orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Estrogen receptor (ESR1) drives growth in the majority of human breast cancers by binding to regulatory elements and inducing… (More)
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Highly Cited
2013
Highly Cited
2013
Viruses have global impact through mortality, nutrient cycling and horizontal gene transfer, yet their study is limited by… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND & AIMS Goblet cells (GC) facilitate mucosal protection and epithelial barrier repair, yet the innate immune mechanisms… (More)
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Review
2005
Review
2005
Rapid repair of mucous epithelia is essential for preventing inflammation which is a critical component of cancer progression… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND & AIMS Effective therapeutics for treating acute colitis, caused by disruption of the intestinal epithelial barrier… (More)
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Review
2003
Review
2003
Recent research has examined Akt and Akt-related serine–threonine kinases in signaling cascades that regulate cell survival and… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Systemic therapy options for patients with advanced angiosarcomas are limited, and their prognosis is poor. The idea… (More)
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Review
2001
Review
2001
TFF-peptides (i.e. TFF1, TFF2, TFF3; formerly P-domain peptides, trefoil factors) have been established as secretory products… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND AND AIMS Trefoil factor family (TFF) peptides and the chromosome 11p15.5 mucin glycoproteins are expressed and… (More)
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Highly Cited
1979
Highly Cited
1979
The urotoxicity of oxazaphosphorine cytostatics is not based on their alkylating activity but on the presence of acrolein, which… (More)
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