Cyclophosphamide

Known as: CPM, 2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide, N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide 
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active… (More)

Topic mentions per year

Topic mentions per year

1944-2017
01000200019442016

Papers overview

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Highly Cited
2010
Highly Cited
2010
BACKGROUND On the basis of promising results that were reported in several phase 2 trials, we investigated whether the addition… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Cyclophosphamide and glucocorticoids have been the cornerstone of remission-induction therapy for severe… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Cyclophosphamide induction regimens for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis are effective… (More)
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Highly Cited
2008
Highly Cited
2008
Abnormal accumulation of myeloid-derived suppressor cells (MDSC) is an important mechanism of tumor immune evasion… (More)
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Highly Cited
2006
Highly Cited
2006
CD4+CD25+ regulatory T cells are involved in the prevention of autoimmune diseases and in tumor-induced tolerance. We previously… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND We present the combined results of two trials that compared adjuvant chemotherapy with or without concurrent… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE Fludarabine and cyclophosphamide (FC), which are active in treatment of chronic lymphocytic leukemia (CLL), are… (More)
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Highly Cited
2005
Highly Cited
2005
Regulatory T cells (T(REGs)) control the key aspects of tolerance and play a role in the lack of antitumor immune responses… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND The HER2 gene, which encodes the growth factor receptor HER2, is amplified and HER2 is overexpressed in 25 to 30… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Chemotherapy combinations that include an alkylating agent and a platinum coordination complex have high response… (More)
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