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Cyclophosphamide

Known as: CPM, 2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide, N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide 
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active… 
National Institutes of Health

Related topics

Related topics

47 relations

Narrower (15)

4-methylcyclophosphamideACP protocolCEOP-B protocolCISCA protocol
CEV regimenCFP protocolCHOP protocol-cyclophosphamide/doxorubicin/prednisone/vincristineCMF-B protocol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis…
Highly Cited
2010
Highly Cited
2010
Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a…
Highly Cited
2008
Highly Cited
2008
Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy
Abnormal accumulation of myeloid-derived suppressor cells (MDSC) is an important mechanism of tumor immune evasion… 
Highly Cited
2006
Highly Cited
2006
Phase III trial comparing doxorubicin plus cyclophosphamide with docetaxel plus cyclophosphamide as adjuvant therapy for operable breast cancer.
PURPOSE The combination of doxorubicin and cyclophosphamide (AC) is a standard adjuvant chemotherapy regimen. Studies of… 
Highly Cited
2000
Highly Cited
2000
Randomized intergroup trial of cisplatin-paclitaxel versus cisplatin-cyclophosphamide in women with advanced epithelial ovarian cancer: three-year results.
BACKGROUND A randomized trial conducted by the Gynecologic Oncology Group (GOG, study #111) in the United States showed a better… 
Highly Cited
1990
Highly Cited
1990
Two months of doxorubicin-cyclophosphamide with and without interval reinduction therapy compared with 6 months of cyclophosphamide, methotrexate, and fluorouracil in positive-node breast cancer…
The National Surgical Adjuvant Breast and Bowel Project (NSABP) implemented protocol B-15 to compare 2 months of Adriamycin… 
Highly Cited
1985
Highly Cited
1985
Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450.
Highly Cited
1983
Highly Cited
1983
Marrow transplantation for acute nonlymphocytic leukemia after treatment with busulfan and cyclophosphamide.
Fifty-one patients with acute nonlymphocytic leukemia (16 with end-stage disease, 17 in second or third remission or in early… 
Highly Cited
1982
Highly Cited
1982
Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells
On the basis of preceding studies showing that tumor-induced, T cell- mediated immunosuppression serves as an obstacle to… 
Highly Cited
1947
Highly Cited
1947
DISEASE
Background: Little is known about patients who frequently visit the emergency department (ED) for acute exacerbation of chronic… 
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