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trastuzumab

Known as: Anti-p185-HER2, Anti-HER2/c-erbB2 Monoclonal Antibody, Anti-c-ERB-2 
A monoclonal antibody that binds to HER2 (human epidermal growth factor receptor 2), and can kill HER2-positive cancer cells. Monoclonal antibodies… 
National Institutes of Health

Related topics

Related topics

21 relations

Narrower (3)

ABP 980HerceptinPF-05280014
AC-T-T RegimenAntibody-Dependent Cellular CytotoxicityDrug AllergyERBB2 protein, human

Broader (1)

Antineoplastic Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer
Trastuzumab (Herceptin®) is currently used as a treatment for patients whose breast tumors overexpress HER2/ErbB2. Trastuzumab… 
Highly Cited
2008
Highly Cited
2008
HER2 Status and Benefit from Adjuvant Trastuzumab in Breast Cancer
Kobayashi K, Sinasac DS, Iijima M, et al. The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial… 
Highly Cited
1999
Highly Cited
1999
Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers
Previous studies have demonstrated a synergistic interaction between rhuMAb HER2 and the cytotoxic drug cisplatin in human breast… 
Highly Cited
1990
Highly Cited
1990
Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.
The expression of the tumour suppressor gene p53 was analysed in 11 human breast cancer cell lines by immunohistochemistry… 
Highly Cited
1985
Highly Cited
1985
The isolation and characterization of the human helper inducer T cell subset.
Monoclonal antibody anti-4B4 was produced by fusing NS1 myeloma with spleen cells of a mouse immunized with Saguinus oedipus… 
Highly Cited
1985
Highly Cited
1985
Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.
Repeated immunization of normal C57L/J (H-2b) mice with peripheral T cells from BALB.B (H-2b) mice results in the production of… 
Highly Cited
1983
Highly Cited
1983
Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody.
Epidermal growth factor (EGF) at 3 nM maximally inhibits the proliferation of A431 epidermoid carcinoma cells. We show that at… 
Highly Cited
1982
Highly Cited
1982
Correlation of specific keratins with different types of epithelial differentiation: Monoclonal antibody studies
Highly Cited
1980
Highly Cited
1980
A monoclonal antibody to human acute lymphoblastic leukaemia antigen
Previous studies by Greaves1 and others2–6 have demonstrated the existence of an antigen associated with cells from many patients… 
Highly Cited
1980
Highly Cited
1980
A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2.
A hybridoma-secreting monoclonal antibody was produced from the spleen cells of a mouse immunized with human thymocytes. This… 
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