trastuzumab

Known as: Anti-p185-HER2, Anti-HER2/c-erbB2 Monoclonal Antibody, Anti-c-ERB-2 
A monoclonal antibody that binds to HER2 (human epidermal growth factor receptor 2), and can kill HER2-positive cancer cells. Monoclonal antibodies… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Antibody–drug conjugates (ADCs) are one of the fastest growing classes of oncology therapeutics. After half a century of research… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND The anti-human epidermal growth factor receptor 2 (HER2) humanized monoclonal antibody trastuzumab improves the… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Trastuzumab, a monoclonal antibody against human epidermal growth factor receptor 2 (HER2; also known as ERBB2), was… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Preclinical studies in ErbB2-positive cell lines demonstrated a synergistic interaction between lapatinib and trastuzumab… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Trastuzumab--a humanised monoclonal antibody against HER2--has been shown to improve disease-free survival after… (More)
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Review
2007
Review
2007
Rather than too few patients and events[1], low efficacy is the likelier cause of lacking significant improvements in disease… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND We present the combined results of two trials that compared adjuvant chemotherapy with or without concurrent… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Trastuzumab, a recombinant monoclonal antibody against HER2, has clinical activity in advanced breast cancer that… (More)
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Highly Cited
2001
Highly Cited
2001
A BSTRACT Background The HER2 gene, which encodes the growth factor receptor HER2, is amplified and HER2 is overexpressed in 25… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Trastuzumab (Herceptin), an anti-HER2/neu receptor monoclonal antibody that inhibits growth of ErbB2-overexpressing… (More)
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