Herceptin

Known as: Herceptin® 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2018
05010019982018

Papers overview

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Highly Cited
2012
Highly Cited
2012
Akt kinase plays a central role in cell growth, metabolism, and tumorigenesis. The TRAF6 E3 ligase orchestrates IGF-1-mediated… (More)
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Highly Cited
2010
Highly Cited
2010
Inherent and acquired therapeutic resistance in breast cancer remains a major clinical challenge. In human breast cancer samples… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE The purpose of this analysis was to investigate trastuzumab-associated cardiac adverse effects in breast cancer patients… (More)
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Highly Cited
2006
Highly Cited
2006
Antibody-based anticancer agents are promising chemotherapeutic agents. Among these agents, Herceptin (trastuzumab), a humanized… (More)
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Highly Cited
2005
Highly Cited
2005
Overexpression of erbB2 in breast tumors is associated with poor prognosis and is a target of receptor-oriented cancer therapy… (More)
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Highly Cited
2003
Highly Cited
2003
HER2 (also known as Neu, ErbB2) is a member of the epidermal growth factor receptor (EGFR; also known as ErbB) family of receptor… (More)
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Highly Cited
2002
Highly Cited
2002
Malignant tumours secrete factors that enable them to commandeer their own blood supply (angiogenesis), and blocking the action… (More)
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Highly Cited
2002
Highly Cited
2002
We have examined whether inhibition of phosphatidylinositol-3 kinase (PI3K) and its target, the serine/threonine kinase Akt, play… (More)
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Highly Cited
2001
Highly Cited
2001
HER2 is a ligand-less tyrosine kinase receptor of the ErbB family that is frequently overexpressed in breast cancer. It undergoes… (More)
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Highly Cited
2000
Highly Cited
2000
Inhibitory receptors have been proposed to modulate the in vivo cytotoxic response against tumor targets for both spontaneous and… (More)
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