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Dermatologist-level classification of skin cancer with deep neural networks
Skin cancer, the most common human malignancy, is primarily diagnosed visually, beginning with an initial clinical screening and followed potentially by dermoscopic analysis, a biopsy andExpand
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Self-renewal and expansion of single transplanted muscle stem cells
Adult muscle satellite cells have a principal role in postnatal skeletal muscle growth and regeneration. Satellite cells reside as quiescent cells underneath the basal lamina that surrounds muscleExpand
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Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
Environment Matters Stem cells isolated from muscle can be used for muscle regeneration, but only if the stem cells are fresh. Under standard cell culture conditions in the laboratory, muscle stemExpand
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Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies
RNA interference (RNAi) is an important means of eliminating mRNAs, but the intracellular location of RNA-induced silencing complex (RISC) remains unknown. We show here that Argonaute 2, a keyExpand
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Reprogramming towards pluripotency requires AID-dependent DNA demethylation
Reprogramming of somatic cell nuclei to yield induced pluripotent stem (iPS) cells makes possible derivation of patient-specific stem cells for regenerative medicine. However, iPS cell generation isExpand
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Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy
The transplantation of cultured myoblasts into mature skeletal muscle is the basis for a new therapeutic approach to muscle and non-muscle diseases: myoblast-mediated gene therapy. The success ofExpand
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Fast muscle fibers are preferentially affected in Duchenne muscular dystrophy
We show that Duchenne muscular dystrophy (DMD) selectively affects a subset of skeletal muscle fibers specialized for fast contraction. Muscle fiber types were characterized immunohistochemicallyExpand
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Cytoplasmic activation of human nuclear genes in stable heterocaryons
We have induced the stable expression of muscle-specific genes in human nonmuscle cells. Normal diploid human amniocytes were fused with differentiated mouse muscle cells by using polyethyleneExpand
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From marrow to brain: expression of neuronal phenotypes in adult mice.
After intravascular delivery of genetically marked adult mouse bone marrow into lethally irradiated normal adult hosts, donor-derived cells expressing neuronal proteins (neuronal phenotypes)Expand
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Rejuvenation of the aged muscle stem cell population restores strength to injured aged muscles
The elderly often suffer from progressive muscle weakness and regenerative failure. We demonstrate that muscle regeneration is impaired with aging owing in part to a cell-autonomous functionalExpand
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