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CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production
TLDR
Data support the concept that the CD4+CD25+ T cells in normal mice may represent a distinct lineage of “professional” suppressor cells.
Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells
TLDR
Results demonstrate that Helios is potentially a specific marker of thymic-derived T Reg cells and raises the possibility that a significant percentage of Foxp3+ Treg cells are generated extrathymically.
CD4+CD25+ suppressor T cells: more questions than answers
  • E. Shevach
  • Biology, Medicine
    Nature Reviews Immunology
  • 1 June 2002
TLDR
The enhancement of suppressor-cell function might prove useful for the treatment of immune-mediated diseases, whereas the downregulation of these cells might be beneficial for the enhancement of the immunogenicity of vaccines that are specific for tumour antigens.
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
TLDR
It is shown that the persistence of Leishmania major in the skin after healing in resistant C57BL/6 mice is controlled by an endogenous population of CD4+CD25+ regulatory T cells, indicating that the equilibrium established between effector and regulatory T Cells in sites of chronic infection might reflect both parasite and host survival strategies.
Cbl-b regulates the CD28 dependence of T-cell activation
TLDR
It is shown that T cells that are deficient in the adaptor molecule Cbl-b do not require CD28 engagement for interleukin-2 production, and that the C Bl-b-null mutation fully restores T-cell-dependent antibody responses in CD28-/-mice, suggesting that the dysregulation of signalling pathways modulated by Cbl -b may also contribute to human autoimmune diseases such as multiple sclerosis.
Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific
TLDR
Detailed characterization of the CD4+CD25+ population demonstrated that they do not contain memory or activated T cells and that they act through an APC-independent mechanism, demonstrating that their suppressor effector function is completely nonspecific.
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