trabectedin

A tetrahydroisoquinoline alkaloid isolated from the marine tunicate Ecteinascidia turbinata with potential antineoplastic activity. Binding to the… (More)
National Institutes of Health

Papers overview

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2014
2014
To elucidate the mechanisms behind the high sensitivity of myxoid/round cell liposarcoma (MRCL) to trabectedin and the suggested… (More)
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Highly Cited
2013
Highly Cited
2013
There is widespread interest in macrophages as a therapeutic target in cancer. Here, we demonstrate that trabectedin, a recently… (More)
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2013
2013
BACKGROUND This expanded access program (EAP) was designed to provide trabectedin access for patients with incurable soft tissue… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE The objective of this study was to compare the efficacy and safety of trabectedin plus pegylated liposomal doxorubicin… (More)
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Highly Cited
2010
Highly Cited
2010
Inflammatory mediators present in the tumor milieu may promote cancer progression and are considered promising targets of novel… (More)
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Highly Cited
2010
Highly Cited
2010
These guidelines were drawn up following a consensus meeting of UK sarcoma specialists convened under the auspices of the British… (More)
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Highly Cited
2009
Highly Cited
2009
Differentiation is a complex set of events that can be blocked by rearrangements of regulatory genes producing fusion proteins… (More)
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2008
2008
Trabectedin (ET-743, Yondelis) is a natural marine compound with antitumour activity currently undergoing phase II/III clinical… (More)
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Highly Cited
2007
Highly Cited
2007
The objective of this study was to determine the objective response rate in patients with platinum-sensitive and platinum… (More)
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Highly Cited
2005
Highly Cited
2005
Yondelis (Trabectedin) is a novel antitumor agent of marine origin extracted from the tunicate Ecteinascidia turbinata. This… (More)
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