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Ecteinascidin 743

Known as: ET-743, Spiro(6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo(7,8)isoquino(3,2,-b)(3)benzazocine-20,1'(2'H)-isoquinolin)-19-one, 3',4',6,6a,7,13,14,16-Octahydro-5-(acetyloxy)-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-, (6R-(6-alpha,6a-beta,7-beta,13-beta,14-beta,16-alpha,20R*))-, ET 743 
 
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
PURPOSE This nonrandomized multicenter phase II study was performed to evaluate the activity and safety of Ecteinascidin (ET-743… Expand
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Highly Cited
2004
Highly Cited
2004
PURPOSE A multicenter phase II study evaluating efficacy, safety, and pharmacokinetics of ecteinascidin-743 (ET-743) in… Expand
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Highly Cited
2004
Highly Cited
2004
PURPOSE To assess the efficacy of the marine-derived alkaloid ecteinascidin 743 (ET-743) in patients with soft tissue sarcomas… Expand
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Review
2002
Review
2002
Abstract. The oceans are the source of a large group of structurally unique natural products that are mainly accumulated in… Expand
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Highly Cited
2001
Highly Cited
2001
Cytochrome P450 3A4 is an important mediator of drug catabolism that can be regulated by the steroid and xenobiotic receptor (SXR… Expand
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Highly Cited
2001
Highly Cited
2001
The mode of action of Ecteinascidin-743 (ET-743), a marine tetrahydroisoquinoline alkaloid isolated from Ecteinascidia turbinata… Expand
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Highly Cited
2001
Highly Cited
2001
While investigating the novel anticancer drug ecteinascidin 743 (Et743), a natural marine product isolated from the Caribbean sea… Expand
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Highly Cited
2000
Highly Cited
2000
Ecteinascidin-743 (ET-743) is a tetrahydroisoquinoline alkaloid isolated from the tunicate Ecteinascidia turbinata currently… Expand
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Highly Cited
2000
Highly Cited
2000
Ecteinascidin 743 (ET-743), a highly promising marine-based antitumor agent presently in phase II clinical trials, has been shown… Expand
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Highly Cited
1999
Highly Cited
1999
The ecteinascidins (Ets), which are natural products derived from marine tunicates, exhibit potent antitumor activity. Of the… Expand
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