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Ecteinascidin 743

Known as: ET-743, Spiro(6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo(7,8)isoquino(3,2,-b)(3)benzazocine-20,1'(2'H)-isoquinolin)-19-one, 3',4',6,6a,7,13,14,16-Octahydro-5-(acetyloxy)-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-, (6R-(6-alpha,6a-beta,7-beta,13-beta,14-beta,16-alpha,20R*))-, ET 743 
National Institutes of Health

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Related topics

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Broader (1)

trabectedin

Papers overview

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2016
2016
Abstract 3764: Trabectedin activity in patient-derived mesothelioma xenografts
Malignant pleural mesothelioma (MPM) incidence is increased over the past two decades and it is predicted to increase further in… 
2014
2014
Association between the HER 2 Ile 655 Val polymorphism and response to trastuzumab in women with operable primary breast cancer
1979; 35: 549–556. 19. Lan KKG, DeMets DL. Discrete sequential boundaries for clinical trials. Biometrika 1983; 70: 659–663. 20… 
2013
2013
Effects of Trabectedine on tumour growth and metabolism in preclinical models of HER-2 overexpressing ovarian cancer
Target audience: All oncologists and radiologists involved in new therapeutic strategies in ovarian cancer. Introduction… 
2012
2012
ET-743
Over 70% of the earth’s surface is covered by oceans and seas housing numerous organisms with an array of biological diversities… 
2010
2010
eview of Trabectedin ( ET-743 ) : A Unique Ther hanism of Action zio
ownload ectedin (ET-743) is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata, with ical structure… 
2005
2005
Compositions comprising ecteinascidin and a disaccharide
2001
2001
A comparison of limited sampling strategies for prediction of Ecteinascidin 743 clearance when administered as a 24-h infusion
Abstract.Purpose: Ecteinascidin 743 (ET-743) is a novel, marine-derived anticancer agent currently under clinical development for… 
2001
2001
Antitumoral analogs of et-743
Antitumor compounds have the structure Dean exciter when Tina is 5-fused ring of formula (XIV) below: (XIV) The compounds of the… 
2001
2001
Phase I and Pharmacokinetic Study of Ecteinascidin 743 Administered as a 72-Hour Continuous Intravenous Infusion in Patients with Solid Malignancies 1
Ecteinascidin 743 (ET-743) is a cytotoxic tetrahydroisoquinoline alkaloid that covalently binds to DNA in the minor groove. The… 
2001
2001
Synthetic process for the manufacture of an ecteinascidin compound
To provide a process for producing the compound having the condensed ring structure of formula XIV: (XIV) The product as…