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Tetrahydroisoquinolines

Known as: Tetrahydro Isoquinolines, 1,2,3,4-Tetrahydroisoquinolines, Tetrahydroisoquinolines [Chemical/Ingredient] 
A group of ISOQUINOLINES in which the nitrogen containing ring is protonated. They derive from the non-enzymatic Pictet-Spengler condensation of… 
National Institutes of Health

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1,1-pentamethylenetetrahydroisoquinoline1,2,3,4-tetrahydroisoquinoline carboxylic acid3-epi-renieramycin G6,7-dimethoxytetrahydroisoquinoline
In BloodIsoquinolinesagonistsantagonists & inhibitors

Broader (1)

Salsoline Alkaloids

Papers overview

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Highly Cited
2011
Highly Cited
2011
Cu(II) catalyzed oxidation-[3+2] cycloaddition-aromatization cascade: efficient synthesis of pyrrolo [2, 1-a] isoquinolines.
A novel and synthetically efficient Cu(II) catalyzed oxidation-dipolar cycloaddition-aromatization cascade reaction has been… 
Highly Cited
2007
Highly Cited
2007
Synthesis of pyrrolo-isoquinolines related to the lamellarins using silver-catalyzed cycloisomerization/dipolar cycloaddition.
Synthesis of pyrrolo-isoquinolines related to the lamellarin alkaloids employing silver-catalyzed cycloisomerization−dipolar… 
Highly Cited
2003
Highly Cited
2003
New versatile route to the synthesis of tetrahydro-beta-carbolines and tetrahydro-pyrano[3,4-b]indoles via an intramolecular Michael addition catalyzed by InBr3.
A simple multistep synthetic strategy to 4-substituted 1,2,3,4-tetrahydro-beta-carboline and 1,3,4,9-tetrahydro-pyrano[3,4-b… 
Review
2002
Review
2002
N-methylation underlying Parkinson's disease.
1996
1996
Selective inhibition of cyclic AMP-dependent protein kinase by isoquinoline derivatives.
A large series of isoquinoline derivatives was synthesised including derivatives of isoquinoline, isoquinolino[3,4-c]furazan, 1,2… 
Highly Cited
1995
Highly Cited
1995
Inhibition of monoamine oxidase by isoquinoline derivatives. Qualitative and 3D-quantitative structure-activity relationships.
Highly Cited
1993
Highly Cited
1993
N-methylated tetrahydroisoquinolines as dopaminergic neurotoxins.
N-Methylation of dopamine-derived 6,7-dihydroxyisoquinolines produces compounds whose chemical structures are similar to 1-methyl… 
1982
1982
Alcohol drinking in the rat: Increases following intracerebroventricular treatment with tetrahydro-β-carbolines
Highly Cited
1978
Highly Cited
1978
Tetrahydroisoquinolines in the brain: the basis of an animal model of alcoholism.
  • R. D. Myers
  • Alcoholism: Clinical and Experimental Research
  • 1978
  • Corpus ID: 5732087
Quite surprisingly, the direct introduction of THP into the brain induces a remarkable shift in voluntary alcohol intake... Even… 
Highly Cited
1967
Highly Cited
1967
Studies on tetrahydroisoquinolines (THI). I. Bronchodilator activity and structure-activity relationship.
For many years the synthesis of isoquinoline derivatives has been carried out in our Organic Chemistry Research Laboratory. In… 
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