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toborinone

Known as: 6-(3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy)-2(1H)-quinolinone, torborinone 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (4)

Cardiotonic AgentsPhosphodiesterase InhibitorsQuinolonesVasodilator Agents

Narrower (1)

OPC 18790

Papers overview

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2004
2004
Toborinone and olprinone, phosphodiesterase III inhibitors, inhibit human platelet aggregation due to the inhibition of both calcium release from intracellular stores and calcium entry
PurposeWe investigated the inhibitory effects of toborinone and olprinone on human platelet aggregation and calcium mobilization… 
2002
2002
The Pharmacokinetics of Toborinone in Subjects with Congestive Heart Failure and Concomitant Renal Impairment and/or Concomitant Hepatic Impairment
The pharmacokinetics of toborinone was studied in subjects with congestive heart failure (CHF) and concomitant renal and/or… 
2001
2001
Electropharmacologic Effects of a New Phosphodiesterase III Inhibitor, Toborinone (OPC‐18790), Assessed in an In Vivo Canine Model
Summary: Electropharmacologic effects of a new phosphodiesterase (PDE) III inhibitor toborinone (OPC‐18790) were assessed in a… 
Review
2000
Review
2000
Clinical overview of the novel inotropic agent toborinone
Toborinone (OPC-18790, Otsuka Pharmaceutical Co. Ltd, 2(1H) -quinolone,6-[3-[ [3,4-dimethoxyphenyl)methyl] amino]-2-hydroxy prop… 
1999
1999
Study on the Effectiveness of Toborinone (OPC-18790) in the Treatment of Heart Failure in Patients Following Cardiac Surgery
Summary Toborinone ((±)-6-[3-(3,4-dimethoxybenizylamino)-2-hydroxypropoxyl]-2(1H)-quinolinone, CAS 128667-95-8, OPC-18790), a… 
1998
1998
Acute effects of toborinone on vascular capacitance and conductance in experimental heart failure.
BACKGROUND Toborinone (OPC-18790), a phosphodiesterase III inhibitor, enhances cardiac contractility and is an arterial dilator… 
1997
1997
Biotransformation of the novel inotropic agent toborinone (OPC-18790) in rats and dogs. Evidence for the formation of novel glutathione and two cysteine conjugates.
The metabolism of toborinone, (+/-)-6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quin - olinone, a novel inotropic… 
1997
1997
[Effects of toborinone on systemic circulation in patients under general anesthesia].
Patients with suppressed systemic circulation under general anesthesia received a 20-minute continuous infusion of toborinone at… 
1996
1996
Effects of toborinone (OPC-18790), a new positive inotropic agent, on action potential in guinea pig sinoatrial node: compared with milrinone and E-4031.
The effects of toborinone ([(+/-)-6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2 (1H)-quinolinone], OPC-18790), milrinone… 
1996
1996
Positive inotropic and chronotropic effects of toborinone and its electrophysiological properties in the isolated hearts of rabbits and guinea-pigs.
The inotropic and chronotropic actions of toborinone ((+/-)-6-[3-(3,4-dimethoxybenzylamino)-2-hydroxy-propoxy]-2(1H)-qu inolinone… 
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