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Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor‐independent myeloperoxidase‐inhibiting mechanism
Cannabidiol provides potent and long‐lasting neuroprotection through an anti‐inflammatory CB1 receptor‐independent mechanism, suggesting that cannabidio will have a palliative action and open new therapeutic possibilities for treating cerebrovascular disorders. Expand
Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats.
The results suggest that in this repeated cerebral ischemia model, the 4-oxo group and the 2,3-double bond in the C ring of rutin and quercetin are related to their neuroprotective action. Expand
Cannabidiol potentiates pharmacological effects of Δ9-tetrahydrocannabinol via CB1 receptor-dependent mechanism
Cannabidiol potentiated pharmacological effects of Delta(9)-THC via CB(1) receptor-dependent mechanism, which may contribute in setting the basis for interaction of cannabinoids and to find a cannabinoid mechanism in central nervous system. Expand
Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism
The results suggest that cannabidiol inhibits monocyte/macropharge expressing HMGB1 followed by preventing glial activation and neurological impairment induced by cerebral ischemia will open new therapeutic possibilities for post-ischemic injury viaHMGB1-inhibiting mechanism. Expand
Inhibition of Reactive Astrocytes with Fluorocitrate Retards Neurovascular Remodeling and Recovery after Focal Cerebral Ischemia in Mice
It is suggested that reactive astrocytes in peri-infarct cortex may promote neurovascular remodeling, and these glial responses may aid functional recovery after stroke. Expand
Pharmacokinetics of zonisamide and drug interaction with phenobarbital in dogs.
It is suggested that repeated administration of a clinical dose of phenobarbital enhanced the clearance of zonisamide and the enhanced clearance lasted at least 10 weeks after the discontinuation of phenbarbital. Expand
Schizandrin reverses memory impairment in rats
It is suggested that schizandrin reverses scopolamine‐induced memory impairment, in part, by enhancing cholinergic function, and that schzandrin might be useful for treating memory deficits. Expand
Δ9-Tetrahydrocannabinol-induced catalepsy-like immobilization is mediated by decreased 5-HT neurotransmission in the nucleus accumbens due to the action of glutamate-containing neurons
It is suggested that the catalepsy-like immobilization induced by THC is mediated by decreased 5-HT neurotransmission in the nucleus accumbens due to the action of glutamate-containing neurons and that this effect is mechanistically different from HPD-induced catalEPsy. Expand
Δ9-tetrahydrocannabinol (Δ9-THC) prevents cerebral infarction via hypothalamic-independent hypothermia
Abstract Δ9-tetrahydrocannabinol (Δ9-THC), a primary psychoactive constituent of cannabis, has been reported to act as a neuroprotectant via the cannabinoid CB1 receptor. In this study, Δ9-THCExpand
Effects of Single Intratracheal Exposure to Chlorhexidine Gluconate on the Rat Lung
The acute direct action of CHX to the lung was evaluated in rats and it is highly possible that CHX at a concentration of more than 0.1% might directly induce ARDS when aspirated and reaching to the alveoli. Expand